Disturbed neurovascular coupling in hemodialysis patients.
Across-voxel CBF-ALFF correlations
Amplitude of low-frequency fluctuation (ALFF)
Amygdala
Arterial spin labeling (ASL)
CBF/ALFF ratio
Cerebral blood flow (CBF)
End-stage renal disease
Hemodialysis
Neurovascular coupling
Neurovascular unit
Journal
PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
12
2019
accepted:
26
03
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
25
4
2020
Statut:
epublish
Résumé
Altered cerebral blood flow (CBF) and amplitude of low-frequency fluctuation (ALFF) have been reported in hemodialysis patients. However, neurovascular coupling impairments, which provide a novel insight into the human brain, have not been reported in hemodialysis patients. We combined arterial spin labeling (ASL) and blood oxygen level dependent (BOLD) techniques to investigate neurovascular coupling alterations and its relationships with demographic and clinical data in 46 hemodialysis patients and 47 healthy controls. To explore regional neuronal activity, ALFF was obtained from resting-state functional MRI. To measure cerebral vascular response, CBF was calculated from ASL. The across-voxel CBF-ALFF correlations for global neurovascular coupling and CBF/ALFF ratio for regional neurovascular coupling were compared between hemodialysis patients and healthy controls. Two-sample All hemodialysis patients and healthy controls showed significant across-voxel correlations between CBF and ALFF. Hemodialysis patients showed a significantly reduced global CBF-ALFF coupling ( These novel findings reveal that disrupted neurovascular coupling may be a potential neural mechanism in hemodialysis patients.
Sections du résumé
BACKGROUND
BACKGROUND
Altered cerebral blood flow (CBF) and amplitude of low-frequency fluctuation (ALFF) have been reported in hemodialysis patients. However, neurovascular coupling impairments, which provide a novel insight into the human brain, have not been reported in hemodialysis patients.
METHODS
METHODS
We combined arterial spin labeling (ASL) and blood oxygen level dependent (BOLD) techniques to investigate neurovascular coupling alterations and its relationships with demographic and clinical data in 46 hemodialysis patients and 47 healthy controls. To explore regional neuronal activity, ALFF was obtained from resting-state functional MRI. To measure cerebral vascular response, CBF was calculated from ASL. The across-voxel CBF-ALFF correlations for global neurovascular coupling and CBF/ALFF ratio for regional neurovascular coupling were compared between hemodialysis patients and healthy controls. Two-sample
RESULTS
RESULTS
All hemodialysis patients and healthy controls showed significant across-voxel correlations between CBF and ALFF. Hemodialysis patients showed a significantly reduced global CBF-ALFF coupling (
CONCLUSIONS
CONCLUSIONS
These novel findings reveal that disrupted neurovascular coupling may be a potential neural mechanism in hemodialysis patients.
Identifiants
pubmed: 32328355
doi: 10.7717/peerj.8989
pii: 8989
pmc: PMC7166048
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e8989Informations de copyright
© 2020 Jin et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
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