A Polyamine-Based Dinitro-Naphthalimide Conjugate as Substrates for Polyamine Transporters Preferentially Accumulates in Cancer Cells and Minimizes Side Effects

cancer dinitro-naphthalimide conjugate minimized side-effects polyamine polyamine transporter

Journal

Frontiers in chemistry
ISSN: 2296-2646
Titre abrégé: Front Chem
Pays: Switzerland
ID NLM: 101627988

Informations de publication

Date de publication:
2020
Historique:
received: 20 12 2019
accepted: 25 02 2020
entrez: 25 4 2020
pubmed: 25 4 2020
medline: 25 4 2020
Statut: epublish

Résumé

Naphthalimides, such as amonafide and mitonafide in clinical trials, have been developed as antitumor agents for orthotopic tumor. However, the serious side effects in cancer patients limit their applications. Herein, a new class of polyamine-based naphthalimide conjugates

Identifiants

pubmed: 32328475
doi: 10.3389/fchem.2020.00166
pmc: PMC7160362
doi:

Types de publication

Journal Article

Langues

eng

Pagination

166

Informations de copyright

Copyright © 2020 Ma, Li, Li, Yue, Liu, Wang, Xi, Shi, Zhao, Ma, Liu, Guo, Liu, Hou, Wang, Wang, Tian and Xie.

Références

J Med Chem. 2017 Mar 9;60(5):2071-2083
pubmed: 28177238
Lancet. 2012 Mar 31;379(9822):1245-55
pubmed: 22353262
Eur J Med Chem. 2017 Mar 10;128:45-55
pubmed: 28147308
J Med Chem. 2012 Apr 12;55(7):3502-12
pubmed: 22428910
CA Cancer J Clin. 2016 Mar-Apr;66(2):115-32
pubmed: 26808342
J Med Chem. 2019 Dec 26;62(24):11324-11334
pubmed: 31765154
Chem Commun (Camb). 2019 Nov 4;55(85):12865-12868
pubmed: 31599283
Fish Shellfish Immunol. 2017 Apr;63:181-188
pubmed: 28214598
J Med Chem. 2014 May 22;57(10):4023-34
pubmed: 24784222
J Med Chem. 2018 Aug 09;61(15):6814-6829
pubmed: 29990424
Angew Chem Int Ed Engl. 2016 May 23;55(22):6390-5
pubmed: 27058998
Curr Med Chem. 2013;20(13):1694-714
pubmed: 23410168
Front Chem. 2018 Sep 21;6:386
pubmed: 30298127
J Enzyme Inhib Med Chem. 2015 Feb;30(1):126-32
pubmed: 24939105
Chem Soc Rev. 2013 Feb 21;42(4):1601-18
pubmed: 23325367
J Clin Oncol. 2015 Apr 10;33(11):1252-7
pubmed: 25732165
Nat Rev Drug Discov. 2007 May;6(5):373-90
pubmed: 17464296
Eur J Med Chem. 2018 Nov 5;159:393-422
pubmed: 30312931
Eur J Med Chem. 2016 Oct 4;121:110-119
pubmed: 27236067
Nat Rev Cancer. 2018 Nov;18(11):681-695
pubmed: 30181570
J Med Chem. 2013 Jul 25;56(14):5819-28
pubmed: 23841465
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30
pubmed: 26742998
J Med Chem. 2017 Jul 13;60(13):5736-5748
pubmed: 28603992
Molecules. 2015 Dec 24;21(1):E23
pubmed: 26712725
ACS Appl Mater Interfaces. 2018 Apr 18;10(15):12081-12111
pubmed: 29171747
Sci Rep. 2017 Mar 16;7:44743
pubmed: 28300195
Plant Physiol. 2013 Mar;161(3):1392-408
pubmed: 23300166
Int J Cancer. 2018 May 15;142(10):1968-1976
pubmed: 29134652
Cancer Lett. 2016 Oct 28;381(2):380-90
pubmed: 27544906
J Med Chem. 2017 Oct 26;60(20):8606-8619
pubmed: 28976754

Auteurs

Jing Ma (J)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Yingguang Li (Y)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Linrong Li (L)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Kexin Yue (K)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Hanfang Liu (H)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Jiajia Wang (J)

Joint National Laboratory for Antibody Drug Engineering, School of Basic Medicine Science, Henan University, Kaifeng, China.

Zhuoqing Xi (Z)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.
Henan University of Science and Technology Second Affiliated Hospital, Luoyang, China.

Man Shi (M)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Sihan Zhao (S)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Qi Ma (Q)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Sitong Liu (S)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Shudi Guo (S)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Jianing Liu (J)

School of Medicine, Henan University Minsheng College, Kaifeng, China.

Lili Hou (L)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Chaojie Wang (C)

The Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng, China.

Peng George Wang (PG)

Southern University of Science and Technology, School of Medicine, Shenzhen, China.

Zhiyong Tian (Z)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Songqiang Xie (S)

School of Pharmacy, Institute for Innovative Drug Design and Evaluation, Henan University, Kaifeng, China.

Classifications MeSH