Comparison of MRI and VQ-SPECT as a Screening Test for Patients With Suspected CTEPH: CHANGE-MRI Study Design and Rationale.

CTEPH MRI PH VQ-SPECT diagnostic strategy pulmonary embolism

Journal

Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388

Informations de publication

Date de publication:
2020
Historique:
received: 13 11 2019
accepted: 16 03 2020
entrez: 25 4 2020
pubmed: 25 4 2020
medline: 25 4 2020
Statut: epublish

Résumé

The diagnostic strategy for chronic thromboembolic pulmonary hypertension (CTEPH) is composed of two components required for a diagnosis of CTEPH: the presence of chronic pulmonary embolism and an elevated pulmonary artery pressure. The current guidelines require that ventilation-perfusion single-photon emission computed tomography (VQ-SPECT) is used for the first step diagnosis of chronic pulmonary embolism. However, VQ-SPECT exposes patients to ionizing radiation in a radiation sensitive population. The prospective, multicenter, comparative phase III diagnostic trial

Identifiants

DOI: 10.3389/fcvm.2020.00051 PMID: 32328500 PMC: PMC7161347
pubmed: 32328500
doi: 10.3389/fcvm.2020.00051
pmc: PMC7161347
doi:

Banques de données

ClinicalTrials.gov
['NCT02791282']

Types de publication

Journal Article

Langues

eng

Pagination

51

Subventions

Organisme : Wellcome Trust
ID : 205188/Z/16/Z
Pays : United Kingdom
Organisme : British Heart Foundation
ID : SP/14/6/31350
Pays : United Kingdom

Informations de copyright

Copyright © 2020 Lasch, Karch, Koch, Derlin, Voskrebenzev, Alsady, Hoeper, Gall, Roller, Harth, Steiner, Krombach, Ghofrani, Rengier, Heußel, Grünig, Beitzke, Hacker, Lang, Behr, Bartenstein, Dinkel, Schmidt, Kreitner, Frauenfelder, Ulrich, Hamer, Pfeifer, Johns, Kiely, Swift, Wild and Vogel-Claussen.

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Auteurs

Florian Lasch (F)

Institute of Biostatistics, Hannover Medical School, Hanover, Germany.

Annika Karch (A)

Institute of Biostatistics, Hannover Medical School, Hanover, Germany.

Armin Koch (A)

Institute of Biostatistics, Hannover Medical School, Hanover, Germany.

Thorsten Derlin (T)

Department of Nuclear Medicine, Hannover Medical School, Hanover, Germany.

Andreas Voskrebenzev (A)

Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.

Tawfik Moher Alsady (TM)

Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.

Marius M Hoeper (MM)

Department of Pneumology, Hannover Medical School, Hanover, Germany.
Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hanover, Germany.

Henning Gall (H)

Department of Pneumology, Medical University Giessen and Marburg, Giessen, Germany.
Universities of Giessen and Marburg Lung Center, Marburg, Germany.

Fritz Roller (F)

Universities of Giessen and Marburg Lung Center, Marburg, Germany.
Department of Radiology, Medical University Giessen and Marburg, Giessen, Germany.

Sebastian Harth (S)

Universities of Giessen and Marburg Lung Center, Marburg, Germany.
Department of Radiology, Medical University Giessen and Marburg, Giessen, Germany.

Dagmar Steiner (D)

Department of Nuclear Medicine, Medical University Giessen and Marburg, Giessen, Germany.

Gabriele Krombach (G)

Universities of Giessen and Marburg Lung Center, Marburg, Germany.
Department of Radiology, Medical University Giessen and Marburg, Giessen, Germany.

Hossein Ardeschir Ghofrani (HA)

Department of Pneumology, Medical University Giessen and Marburg, Giessen, Germany.
Universities of Giessen and Marburg Lung Center, Marburg, Germany.

Fabian Rengier (F)

Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
Translational Lung Research Center (TLRC) Heidelberg, Member of the German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.

Claus Peter Heußel (CP)

Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany.
Translational Lung Research Center (TLRC) Heidelberg, Member of the German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.
Department of Diagnostic and Interventional Radiology With Nuclear Medicine, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.

Ekkehard Grünig (E)

Translational Lung Research Center (TLRC) Heidelberg, Member of the German Center for Lung Research (DZL), University of Heidelberg, Heidelberg, Germany.
Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany.

Dietrich Beitzke (D)

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.

Marcus Hacker (M)

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.

Irene M Lang (IM)

Department of Cardiology, Internal Medicine II, Medical University of Vienna, Vienna, Austria.

Jürgen Behr (J)

Department of Pneumology, Ludwig-Maximilan University Munich, Munich, Germany.
Comprehensive Pneumology Center, Munich, Ludwig-Maximilians-University Munich and Asklepios Hospital Munich-Gauting and Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.

Peter Bartenstein (P)

Department of Nuclear Medicine, Ludwig-Maximilan University, Munich, Germany.

Julien Dinkel (J)

Comprehensive Pneumology Center, Munich, Ludwig-Maximilians-University Munich and Asklepios Hospital Munich-Gauting and Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.
Department of Radiology, Ludwig-Maximilan University Munich, Munich, Germany.

Kai-Helge Schmidt (KH)

Department of Cardiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Karl-Friedrich Kreitner (KF)

Department of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Thomas Frauenfelder (T)

Department of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland.

Silvia Ulrich (S)

Department of Respiratory Medicine, Pulmonary Hypertension Unit, University Hospital Zurich, Zurich, Switzerland.

Okka W Hamer (OW)

Department of Radiology, Regensburg University Hospital, Regensburg, Germany.

Michael Pfeifer (M)

Department of Pneumology, Regensburg University Hospital, Regensburg, Germany.

Christopher S Johns (CS)

Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom.

David G Kiely (DG)

Sheffield Pulmonary Vascular Disease Unit, Royal Hallamhire Hospital, Sheffield, United Kingdom.

Andrew James Swift (AJ)

Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.

Jim Wild (J)

Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.

Jens Vogel-Claussen (J)

Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.
Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hanover, Germany.

Classifications MeSH