Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions.

Brain Neoplasms / enzymology Chemoradiotherapy Clinical Trials, Phase III as Topic Consensus Glioblastoma / enzymology Humans Isocitrate Dehydrogenase / genetics Randomized Controlled Trials as Topic
clinical trials diagnosis glioblastoma therapy

Journal

Neuro-oncology
ISSN: 1523-5866
Titre abrégé: Neuro Oncol
Pays: England
ID NLM: 100887420

Informations de publication

Date de publication:
17 08 2020
Historique:
pubmed: 25 4 2020
medline: 7 4 2021
entrez: 25 4 2020
Statut: ppublish

Résumé

Glioblastomas are the most common form of malignant primary brain tumor and an important cause of morbidity and mortality. In recent years there have been important advances in understanding the molecular pathogenesis and biology of these tumors, but this has not translated into significantly improved outcomes for patients. In this consensus review from the Society for Neuro-Oncology (SNO) and the European Association of Neuro-Oncology (EANO), the current management of isocitrate dehydrogenase wildtype (IDHwt) glioblastomas will be discussed. In addition, novel therapies such as targeted molecular therapies, agents targeting DNA damage response and metabolism, immunotherapies, and viral therapies will be reviewed, as well as the current challenges and future directions for research.

Identifiants

DOI: 10.1093/neuonc/noaa106 PMID: 32328653 PMC: PMC7594557
pubmed: 32328653
pii: 5824407
doi: 10.1093/neuonc/noaa106
pmc: PMC7594557
doi:

Substances chimiques

Isocitrate Dehydrogenase EC 1.1.1.41

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1073-1113

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS110942
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA069246
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS105109
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA211015
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA163205
Pays : United States

Commentaires et corrections

Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn

Informations de copyright

© The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Auteurs

Patrick Y Wen (PY)

Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Michael Weller (M)

Department of Neurology and Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.

Eudocia Quant Lee (EQ)

Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Brian M Alexander (BM)

Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Jill S Barnholtz-Sloan (JS)

Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio, USA.

Floris P Barthel (FP)

The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.

Tracy T Batchelor (TT)

Department of Neurology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School.

Ranjit S Bindra (RS)

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, USA.

Susan M Chang (SM)

University of California San Francisco, San Francisco, California, USA.

E Antonio Chiocca (EA)

Department of Neurosurgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.

Timothy F Cloughesy (TF)

David Geffen School of Medicine, Department of Neurology, University of California Los Angeles, Los Angeles, California, USA.

John F DeGroot (JF)

Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Evanthia Galanis (E)

Mayo Clinic, Rochester, Minnesota, USA.

Mark R Gilbert (MR)

Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Monika E Hegi (ME)

Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Craig Horbinski (C)

Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Raymond Y Huang (RY)

Division of Neuroradiology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Andrew B Lassman (AB)

Department of Neurology and Herbert Irving Comprehensive Cancer Center, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA.

Emilie Le Rhun (E)

University of Lille, Inserm, Neuro-oncology, General and Stereotaxic Neurosurgery service, University Hospital of Lille, Lille, France; Breast Cancer Department, Oscar Lambret Center, Lille, France and Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.

Michael Lim (M)

Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Minesh P Mehta (MP)

Miami Cancer Institute, Miami, Florida, USA.

Ingo K Mellinghoff (IK)

Department of Neurology and Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Giuseppe Minniti (G)

Radiation Oncology Unit, Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.

David Nathanson (D)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, USA.

Michael Platten (M)

Department of Neurology, Medical Faculty Mannheim, MCTN, Heidelberg University, Heidelberg, Germany.

Matthias Preusser (M)

Division of Oncology, Department of Medicine, Medical University of Vienna, Vienna, Austria.

Patrick Roth (P)

Department of Neurology and Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.

Marc Sanson (M)

Sorbonne Université, Inserm, CNRS, UMR S 1127, Institut du Cerveau et de la Moelle épinière, ICM, AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neurologie 2-Mazarin, Paris, France.

David Schiff (D)

University of Virginia School of Medicine, Division of Neuro-Oncology, Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.

Susan C Short (SC)

Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.

Martin J B Taphoorn (MJB)

Department of Neurology, Medical Center Haaglanden, The Hague and Department of Neurology, Leiden University Medical Center, the Netherlands.

Joerg-Christian Tonn (JC)

Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany.

Jonathan Tsang (J)

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, USA.

Roel G W Verhaak (RGW)

The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.

Andreas von Deimling (A)

Neuropathology and Clinical Cooperation Unit Neuropathology, University Heidelberg and German Cancer Center, Heidelberg, Germany.

Wolfgang Wick (W)

Department of Neurology and Neuro-oncology Program, National Center for Tumor Diseases, Heidelberg University Hospital, Heidelberg, Germany.

Gelareh Zadeh (G)

MacFeeters Hamilton Centre for Neuro-Oncology Research, Princess Margaret Cancer Centre, Toronto, Canada.

David A Reardon (DA)

Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Kenneth D Aldape (KD)

Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

Martin J van den Bent (MJ)

Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.

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Classifications MeSH

questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs du cerveau › Glioblastoma in adults: a Society for...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Chimioradiothérapie › Glioblastoma in adults: a Society for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques de phase III comme sujet › Glioblastoma in adults: a Society for...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Pensée (activité mentale) › Prise de décision › Consensus › Glioblastoma in adults: a Society for...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroépitheliales › Gliome › Astrocytome › Glioblastome › Glioblastoma in adults: a Society for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Glioblastoma in adults: a Society for...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › Isocitrate dehydrogenases › Glioblastoma in adults: a Society for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › Glioblastoma in adults: a Society for...