Effect of Platinum Nanoparticles on the Structure of Protein Molecules and Regulation of the Tone of Brain Vessels in Experimental Animals.
Animals
Animals, Outbred Strains
Blood Flow Velocity
/ physiology
Brain
/ diagnostic imaging
Cerebral Arteries
/ diagnostic imaging
Cerebrovascular Circulation
/ physiology
Contrast Media
/ administration & dosage
Laser-Doppler Flowmetry
/ methods
Male
Metal Nanoparticles
/ administration & dosage
Platinum
/ administration & dosage
Rats
blood serum
cuneiform dehydration method
experimental animals
laser doppler flowmetry
platinum nanoparticles
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
13
06
2019
pubmed:
25
4
2020
medline:
16
3
2021
entrez:
25
4
2020
Statut:
ppublish
Résumé
The effects of platinum nanoparticles on the morphological structures of the solid phase of blood serum and the tone of cerebral microvessels as indicators of the dynamics of homeostasis were studied on outbred albino male rats (n=40) weighing 300-350 g. Platinum nanoparticles were injected to experimental animals in 1 ml of physiological saline. For systemic BP measurements and blood sampling, the femoral artery was isolated and catheterized. The study of solid phase structures of blood serum was conducted by the method of cuneiform dehydration. The results showed that injection of platinum nanoparticles significantly affected the body of experimental animals.
Identifiants
pubmed: 32328947
doi: 10.1007/s10517-020-04801-0
pii: 10.1007/s10517-020-04801-0
doi:
Substances chimiques
Contrast Media
0
Platinum
49DFR088MY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM