Investigation of Effects of Two Chronic Stress Protocols on Depression-Like Behaviors and Brain Mineral Levels in Female Rats: an Evaluation of 7-Day Immobilization Stress.
Anxiety
Brain
Copper
Depression
Immobilization
Manganese
Rat
Zinc
Journal
Biological trace element research
ISSN: 1559-0720
Titre abrégé: Biol Trace Elem Res
Pays: United States
ID NLM: 7911509
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
28
02
2020
accepted:
15
04
2020
pubmed:
25
4
2020
medline:
22
6
2021
entrez:
25
4
2020
Statut:
ppublish
Résumé
We aimed to investigate the effects of two different chronic immobilization stress protocols on depression-related behaviors and brain mineral levels. Adult female Wistar albino rats were divided into 3 groups as follows (n = 10/group): control, immobilization stress-1 (45 min daily for 7 days), and immobilization stress-2 (45 min twice a day for 7 day). Stress-related behavior was evaluated by means of the forced swimming test (FST) and open field test (OFT). Minerals were analyzed using an inductively coupled plasma mass spectrometer. In the FST, swimming and immobility were significantly lower in the immobilization stress-1 and immobilization stress-2 groups. The climbing duration of the immobilization stress-2 group was higher than the control group. In the OFT, percentage of time spent in the central area was significantly lower in the immobilization stress-1 and immobilization stress-2 groups. Values of latency to center area, rearing, and grooming did not significantly differ between groups. In the immobilization stress-1 group, zinc was lower, and iron, copper, and manganese were higher than the control group. In the immobilization stress-2 group, copper and manganese were higher, and phosphate was lower than the control group. Our results showed that depression-related behaviors were more dominant in the immobilization stress-1 group. A decrease in the brain zinc level was valid only for the immobilization stress-1 group. These results point to the role of low brain zinc levels in the pathophysiology of depression.
Identifiants
pubmed: 32328969
doi: 10.1007/s12011-020-02160-5
pii: 10.1007/s12011-020-02160-5
doi:
Substances chimiques
Minerals
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
660-667Références
Anisman H, Matheson K (2005) Stress, depression, and anhedonia: caveats concerning animal models. Neurosci Biobehav Rev 29(4–5):525–546
pubmed: 15925696
Schneiderman N, Ironson G, Siegel SD (2005) Stress and health: psychological, behavioral, and biological determinants. Annu Rev Clin Psychol 1:607–628
pubmed: 17716101
pmcid: 2568977
McEwen BS (2008) Understanding the potency of stressful early life experiences on brain and body function. Metabolism 57(Suppl 2):S11–S15
pubmed: 18803958
pmcid: 2567059
Şahin Z, Özkürkçüler A, Koç A et al (2019) An evaluation of the effects of two chronic immobilization stress protocols on depression/anxiety-related behavior in male rats. ACU Sağlık Bil Derg 10(3):535–541
Jaggi AS, Bhatia N, Kumar N, Singh N, Anand P, Dhawan R (2011) A review on animal models for screening potential anti-stress agents. Neurol Sci 32:993–1005
pubmed: 21927881
Bali A, Jaggi AS (2015) Preclinical experimental stress studies: protocols, assessment and comparison. Eur J Pharmacol 746:282–292
pubmed: 25446911
Sahin Z, Koc A, Ozen Koca R et al (2019) Comparison of effects of three distinct stress models on anxiety- and depression-related behaviors in female rats. Sakarya Med J 9(1):131–140
Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, Murray CJL, Vos T, Whiteford HA (2013) Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Med 10(11):e1001547
pubmed: 24223526
pmcid: 3818162
Depression and Other Common Mental Disorders: Global Health Estimates (2017). Geneva: World Health Organization. Licence: CC BY-NC-SA 3.0 IGO.p:8–12
Trivedi MH, Rush AJ, Wisniewski SR, Nierenberg AA, Warden D, Ritz L, Norquist G, Howland RH, Lebowitz B, McGrath PJ, Shores-Wilson K, Biggs MM, Balasubramani GK, Fava M, STAR*D Study Team (2006) Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry 163(1):28–40
pubmed: 16390886
Gartlehner G, Hansen RA, Morgan LC, et al (2011) Second-generation antidepressants in the pharmacologic treatment of adult depression: an update of the 2007 comparative effectiveness review. (prepared by the RTI International–University of North Carolina Evidence-based Practice Center, Contract No. 290-2007-10056-I.) AHRQ Publication No. 12-EHC012-EF. Rockville, MD: Agency for Healthcare Research and Quality. December 2011
Wilson S, Vaidyanathan U, Miller MB, McGue M, Iacono WG (2014) Premorbid risk factors for major depressive disorder: are they associated with early onset and recurrent course? Dev Psychopathol 26:1477–1493
pubmed: 25422974
pmcid: 4244653
Fraga CG (2005) Relevance, essentiality and toxicity of trace elements in human health. Mol Asp Med 26:235–244
Alimonti A, Ristori G, Giubilei F, Stazi MA, Pino A, Visconti A, Brescianini S, Monti MS, Forte G, Stanzione P, Bocca B, Bomboi G, D’Ippolito C, Annibali V, Salvetti M, Sancesario G (2007) Serum chemical elements and oxidative status in Alzheimer’s disease, Parkinson disease and multiple sclerosis. Neurotoxicology 28:450–456
pubmed: 17267042
Mustak MS, Rao TS, Shanmugavelu P et al (2008) Assessment of serum macro and trace element homeostasis and the complexity of inter-element relations in bipolar mood disorders. Clin Chim Acta 394(1-2):47–53
pubmed: 18457668
Nahar Z, Azad MA, Rahman MA et al (2010) Comparative analysis of serum manganese, zinc, calcium, copper and magnesium level in panic disorder patients. Biol Trace Elem Res 133:284–290
pubmed: 19582379
Shohag H, Ullah A, Qusar S, Rahman M, Hasnat A (2012) Alterations of serum zinc, copper, manganese, iron, calcium, and magnesium concentrations and the complexity of interelement relations in patients with obsessive-compulsive disorder. Biol Trace Elem Res 148:275–280
pubmed: 22383079
Błażewicz A, Liao KY, Liao HH et al (2017) Alterations of hair and nail content of selected trace elements in nonoccupationally exposed patients with chronic depression from different geographical regions. Biomed Res Int 2017:3178784
pubmed: 28386550
pmcid: 5366181
Wang J, Um P, Dickerman BA, Liu J (2018) Zinc, magnesium, selenium and depression: a review of the evidence, potential mechanisms and implications. Nutrients 10(5)
Murck H (2002) Magnesium and affective disorders. Nutr Neurosci 5:375–389
pubmed: 12509067
Sahin Z, Solak H, Koc A, Ozen Koca R, Ozkurkculer A, Cakan P, Solak Gormus ZI, Kutlu S, Kelestimur H (2019) Long-term metabolic cage housing increases anxiety/depression-related behaviours in adult male rats. Arch Physiol Biochem 125(2):122–127
pubmed: 29463132
Rattanachongkiat S, Millward GE, Foulkes ME (2004) Determination of arsenic species in fish, crustacean and sediment samples from Thailand using high performance liquid chromatography (HPLC) coupled with inductively coupled plasma mass spectrometry (ICPMS). J Environ Monit 6(4):254–261
pubmed: 15054532
De Blas BI, Sanz Castro R, López Riquelme N, Tormo Díaz C, Apraiz Goyenaga D (2007) Optimization of the trace element determination by ICP-MS in human blood serum. J Trace Elem Med Biol 21(Suppl 1):14–17
Castagné V, Moser P, Roux S, Porsolt RD (2011) Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice. Curr Protoc Neurosci Chapter 8:Unit 8.10A
Canpolat S, Ulker N, Yardimci A, Bulmus O, Ozdemir G, Sahin Z, Ercan Z, Serhatlioglu I, Kacar E, Ozcan M, Turk G, Ozkan Y, Atmaca M, Yilmaz B, Kelestimur H (2016) Studies on the reproductive effects of chronic treatment with agomelatine in the rat. Eur J Pharmacol 770:33–39
pubmed: 26643170
Cryan JF, Mombereau C (2004) In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry 9:326–357
pubmed: 14743184
Cryan JF, Page ME, Lucki I (2005) Differential behavioral effects of the anti-depressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment. Psychopharmacology 182:335–344
pubmed: 16001105
Veena J, Srikumar BN, Raju TR, Shankaranarayana Rao BS (2009) Exposure to enriched environment restores the survival and differentiation of new born cells in the hippocampus and ameliorates depressive symptoms in chronically stressed rats. Neurosci Lett 455:178–182
pubmed: 19429116
Suvrathan A, Tomar A, Chattarji S (2010) Effects of chronic and acute stress on rat behaviour in the forced-swim test. Stress 13:533–540
pubmed: 20666651
Lee B, Yun HY, Shim I, Lee H, Hahm DH (2012) Bupleurum falcatum prevents depression and anxiety-like behaviors in rats exposed to repeated restraint stress. J Microbiol Biotechnol 22:422–430
pubmed: 22450800
Page ME, Detke MJ, Dalvi A, Kirby LG, Lucki I (1999) Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test. Psychopharmacology 147:162–167
pubmed: 10591883
Lam VYY, Raineki C, Takeuchi LE, Ellis L, Woodward TS, Weinberg J (2018) Chronic stress alters behavior in the forced swim test and underlying neural activity in animals exposed to alcohol prenatally: sex- and time-dependent effects. Front Behav Neurosci 12:42
pubmed: 29593510
pmcid: 5855032
Anyan J, Amir S (2018) Too depressed to swim or too afraid to stop? A reinterpretation of the forced swim test as a measure of anxiety-like behavior. Neuropsychopharmacology 43(5):931–933
pubmed: 29210364
American Psychiatric Association DSM-5 (2013) Diagnostic and statistical manual of mental disorders, Fifth edn. APA, Washington DC
Şahin Z, Özen Koca R, Solak H et al (2019) Comparison of the effects of immobilization stress and chronic mild stress models on depression-related behaviors in female rats: an assessment of a 10-day stress period. FU Med J Health Sci 33(3):153–157
Belovicova K, Bogi E, Csatlosova K, Dubovicky M (2017) Animal tests for anxiety-like and depression-like behavior in rats. Interdiscip Toxicol 10:40–43
pubmed: 30123035
Herzog DP, Wegener G, Lieb K, Müller MB, Treccani G (2019) Decoding the mechanism of action of rapid-acting antidepressant treatment strategies: does gender matter? Int J Mol Sci 20:E949
pubmed: 30813226
Ampuero E, Luarte A, Santibañez M et al (2015) Two chronic stress models based on movement restriction in rats respond selectively to antidepressant drugs: aldolase C as a potential biomarker. Int J Neuropsychopharmacol 18(10):pyv038
pubmed: 25813018
pmcid: 4648154
Son H, Yang JH, Kim HJ, Lee DK (2019) A chronic immobilization stress protocol for inducing depression-like behavior in mice. J Vis Exp 147. https://doi.org/10.3791/59546
Ames BN, Elson-Schwab I, Silver EA (2002) High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased km): relevance to genetic disease and polymorphisms. Am J Clin Nutr 75:616–658
pubmed: 11916749
Tokdemir M (2003) Blood zinc and copper concentrations in criminal and non-criminal schizophrenic men. Arch Androl 49:365–368
pubmed: 12893514
Walsh WJ, Issacson HR, Hall A (1997) Elevated blood copper/zinc ratios in assaultive young males. Physiol Behav 62:327–329
pubmed: 9251975
Hubbard PC, Lummis SCR (2000) Zn2+ enhancement of the recombinant 5-HT(3) receptor is modulated by divalent cations. Eur J Pharmacol 394:189–197
pubmed: 10771284
Plum LM, Rink L, Haase H (2010) The essential toxin: impact of zinc on human health. Int J Environ Res Public Health 7(4):1342–1365
pubmed: 20617034
pmcid: 2872358
Szewczyk B, Poleszak E, Wlaź P, Wróbel A, Blicharska E, Cichy A, Dybała M, Siwek A, Pomierny-Chamioło L, Piotrowska A, Brański P, Pilc A, Nowak G (2009) The involvement of serotonergic system in the antidepressant effect of zinc in the forced swim test. Prog Neuro-Psychopharmacol Biol Psychiatry 33(2):323–329
Jung KI, Ock SM, Chung JH, Song CH (2010) Associations of serum Ca and Mg levels with mental health in adult women without psychiatric disorders. Biol Trace Elem Res 133:153–161
pubmed: 19543697
Barragan-Rodriguez L, Rodriguez-Moran M, Guerrero-Romero F (2007) Depressive symptoms and hypomagnesemia in older diabetic subjects. Arch Med Res 38(7):752–756
pubmed: 17845894
Sowa-Kucma M, Szewczyk B, Sadlik K et al (2013) Zinc, magnesium and nmda receptor alterations in the hippocampus of suicide victims. J Affect Disord 151(3):924–931
pubmed: 24055117
Szewczyk B, Szopa A, Serefko A, Poleszak E, Nowak G (2018) The role of magnesium and zinc in depression: similarities and differences. Magnes Res 31(3):78–89
pubmed: 30714573
Tarleton EK, Littenberg B, MacLean CD, Kennedy AG, Daley C (2017) Role of magnesium supplementation in the treatment of depression: a randomized clinical trial. PLoS One 12:e0180067
pubmed: 28654669
pmcid: 5487054
Serefko A, Szopa A, Wlaź P, Nowak G, Radziwoń-Zaleska M, Skalski M, Poleszak E (2013) Magnesium in depression. Pharmacol Rep 65:547–554
pubmed: 23950577
Li Y, Zheng Y, Qian J, Chen X, Shen Z, Tao L, Li H, Qin H, Li M, Shen H (2012) Preventive effects of zinc against psychological stress-induced iron dyshomeostasis, erythropoiesis inhibition, and oxidative stress status in rats. Biol Trace Elem Res 147:285–291
pubmed: 22274754
Ferreira A, Neves P, Gozzelino R (2019) Multilevel impacts of Iron in the brain: the cross talk between neurophysiological mechanisms, cognition, and social behavior. Pharmaceuticals (Basel) 12(3):126
Lehmann ML, Weigel TK, Elkahloun AG, Herkenham M (2017) Chronic social defeat reduces myelination in the mouse medial prefrontal cortex. Sci Rep 7:46548
pubmed: 28418035
pmcid: 5394533
Zuo LJ, Yu SY, Hu Y, Wang F, Piao YS, Lian TH, Yu QJ, Wang RD, Li LX, Guo P, du Y, Zhu RY, Jin Z, Wang YJ, Wang XM, Chan P, Chen SD, Wang YJ, Zhang W (2016) Serotonergic dysfunctions and abnormal iron metabolism: relevant to mental fatigue of Parkinson disease. Sci Rep 6(1):19
pubmed: 28442790
pmcid: 5431345
Beard JL, Connor JR (2003) Iron status and neural functioning. Annu Rev Nutr 23:41–58
pubmed: 12704220
Nnah IC, Wessling-Resnick M (2018) Brain Iron homeostasis: a focus on microglial iron. Pharmaceuticals (Basel) 11(4)
Takeda A (2000) Movement of zinc and its functional significance in the brain. Brain Res Brain Res Rev 34(3):137–148
pubmed: 11113504
Crayton J, Walsh W (2007) Elevated serum copper levels in women with a history of post-partum depression. J Trace Elem Med Biol 14:17–21
Russo AJ (2011) Decreased zinc and increased copper in individuals with anxiety. Nutr Metab Insights 4:1–5
pubmed: 23946656
pmcid: 3738454
Maddock RJ, Moses JA Jr, Roth WT, King R, Murchison A, Berger PA (1987) Serum phosphate and anxiety in major depression. Psychiatry Res 22(1):29–36
pubmed: 3659218
Thi Thu Nguyen T, Miyagi S, Tsujiguchi H et al (2019) Association between lower intake of minerals and depressive symptoms among elderly Japanese women but not men: findings from Shika Study. Nutrients 11(2)