Investigation of amino acids and minerals in Chinese breast milk.
amino acids
human milk
minerals
Journal
Journal of the science of food and agriculture
ISSN: 1097-0010
Titre abrégé: J Sci Food Agric
Pays: England
ID NLM: 0376334
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
03
02
2020
revised:
13
04
2020
accepted:
24
04
2020
pubmed:
25
4
2020
medline:
29
1
2021
entrez:
25
4
2020
Statut:
ppublish
Résumé
The nutrients in human milk, particularly amino acids and minerals, are important for infant growth and development. Since there are few reports of amino acids and minerals in Chinese breast milk, we conducted this study to establish a representative preliminary database of breast milk nutrients in Chinese breast milk. In this study, we collected breast milk from healthy mothers in seven cities in western, southern and central China. The composition, content and proportion of total amino acids and ten elements (potassium, sodium, calcium, magnesium, iron, zinc, manganese, copper, selenium and phosphorus) in human milk in different lactation stages were investigated. In this study, it was found that the content of total essential amino acids (671.47 mg 100 mL In a word, amino acids and minerals in Chinese human milk showed a significant difference from other countries. Human milk meal or infant food should be regulated to meet the requirements of the infant and to maintain the balance of the amino acids and minerals. © 2020 Society of Chemical Industry.
Sections du résumé
BACKGROUND
BACKGROUND
The nutrients in human milk, particularly amino acids and minerals, are important for infant growth and development. Since there are few reports of amino acids and minerals in Chinese breast milk, we conducted this study to establish a representative preliminary database of breast milk nutrients in Chinese breast milk. In this study, we collected breast milk from healthy mothers in seven cities in western, southern and central China. The composition, content and proportion of total amino acids and ten elements (potassium, sodium, calcium, magnesium, iron, zinc, manganese, copper, selenium and phosphorus) in human milk in different lactation stages were investigated.
RESULTS
RESULTS
In this study, it was found that the content of total essential amino acids (671.47 mg 100 mL
CONCLUSIONS
CONCLUSIONS
In a word, amino acids and minerals in Chinese human milk showed a significant difference from other countries. Human milk meal or infant food should be regulated to meet the requirements of the infant and to maintain the balance of the amino acids and minerals. © 2020 Society of Chemical Industry.
Substances chimiques
Amino Acids
0
Minerals
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3920-3931Subventions
Organisme : the National Natural Science Foundation of China
ID : 31660447
Informations de copyright
© 2020 Society of Chemical Industry.
Références
Lebouder E, Rey-Nores JE, Raby A-C, Affolter M, Vidal K, Thornton CA et al., Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk. J Immunol 176:3742-3752 (2006).
Fragiadakis GK, Smits SA, Sonnenburg ED, Van Treuren W, Reid G, Knight R et al., Links between environment, diet, and the hunter-gatherer microbiome. Gut Microbes 10:216-227 (2019).
Grześkowiak ŁM, Pieper R, Huynh HA, Cutting SM, Vahjen W and Zentek J, Impact of early-life events on the susceptibility to Clostridium difficile colonisation and infection in the offspring of the pig. Gut Microbes. 10:251-259 (2019).
Wu J, Ma N, Johnston LJ and Ma X, Dietary nutrients mediate intestinal host defense peptide expression. Adv Nutr 11:92-102 (2020).
Sun M, Ma N, He T, Johnston LJ and Ma X, Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR). Crit Rev Food Sci Nutr 60:1760-1768 (2019).
Jia H, He T, Yu H, Zeng X, Zhang S, Ma W et al., Effects of L-lysine· H2SO4 product on the intestinal morphology and liver pathology using broiler model. J Anim Sci Biotechnol 10:10 (2019).
Garcia-Rodenas C, Affolter M, Vinyes-Pares G, De Castro C, Karagounis L, Zhang Y et al., Amino acid composition of breast milk from urban chinese mothers. Nutrients 8:606 (2016).
Chuang CK, Lin S-P, Lee H-C, Wang T-J, Shih Y-S, Huang F-Y et al., Free amino acids in full-term and pre-term human milk and infant formula. J Pediatr Gastr Nutr. 40:496-500 (2005).
Harzer G, Franzke V and Bindels JG, Human milk nonprotein nitrogen components: changing patterns of free amino acids and urea in the course of early lactation. Am J Clin Nutr 40:303-309 (1984).
Ln B, Effects of maternal dietary intake on human milk composition. J Nutr 116:499-513 (1986).
Zhang Z, Alicia A, Deshanie R, Julia B and Ln B, Amino acid profiles in term and preterm human milk through lactation: a systematic review. Nutrients 5:4800-4821 (2013).
Ding M, Li W, Zhang Y, Wang X, Zhao A, Zhao X et al., Amino acid composition of lactating mothersʼ milk and confinement diet in rural north China. Asia Pac J Clin Nutr 19:344-349 (2010).
Pang JZ, Liu ZD, Jia N, Li JF, Pei CH, Mi LJ et al., Longitudinal study of protein content and amino acid composition of breast milk at different lactation stages from southern and northern urban Chinese mothers. Food Sci 40:167-174 (2019).
Bo L, Nutritional and physiologic significance of human milk proteins. Am J Clin Nutr 77:1537S-1543S (2003).
Feng P, Gao M, Holley T, Zhou T, Burgher A, Trabulsi J et al., Amino acid composition and protein content of mature human milk from nine countries. FASEB J 23:LB448-LB (2009).
Wu T-C, Chuang C-C, Lau B-H, Hwang B, SUGAWARA M and IDOTA T, Crude protein content and amino acid composition in Taiwanese human milk. J Nutr Sci Vitaminol 46:246-251 (2000).
He BZ, Sun XJ, Quan MY and Wang DH, Macronutrients and energy in milk from mothers of premature infants. Chin J Contemp Pediatr 16:679-683 (2014).
Liu J, Study on the mineral contents of 113 human milks in Huhhot. Food Res Dev 37:117-119 (2016).
QS Medeiros PH, Ledwaba SE, Bolick DT, Giallourou N, Yum LK, Costa DV et al., A murine model of diarrhea, growth impairment and metabolic disturbances with Shigella flexneri infection and the role of zinc deficiency. Gut Microbes. 10:615-630 (2019).
Vaughan L, Weber C and Kemberling S, Longitudinal changes in the mineral content of human milk. Am J Clin Nutr 32:2301-2306 (1979).
Karra MV, Kirksey A, Galal O, Bassily N, Harrison GG and Jerome NW, Zinc, calcium, and magnesium concentrations in milk from American and Egyptian women throughout the first 6 months of lactation. Am J Clin Nutr 47:642-648 (1988).
Lin T-H, Jong Y-J and Yang M-H, Longitudinal changes in Ca, Mg, Fe, Cu, and Zn in breast milk of women in Taiwan over a lactation period of one year. Biol Trace Elem Res 62:31-41 (1998).
Sun JH and Xie EP, Breatfeeding and neonatal immunity. J Clin Pediatr 30:204-207 (2012).
Sabatier M, Garcia-Rodenas CL, De Castro CA, Kastenmayer P, Vigo M, Dubascoux S et al., Longitudinal changes of mineral concentrations in preterm and term human milk from lactating Swiss women. Nutrients 11:1855 (2019).
Dror DK and Allen LH, Overview of nutrients in human milk. Adv Nutr 9:278S-294S (2018).
Zhao A, Ning Y, Zhang Y, Yang X, Wang J, Li W et al., Mineral compositions in breast milk of healthy Chinese lactating women in urban areas and its associated factors. Chin Med J 127:2643-2648 (2014).
Ereman RR, Lönnerdal B and Dewey KG, Maternal sodium intake does not affect postprandial sodium concentrations in human milk. J Nutr 117:1154-1157 (1987).
Funk MA, Hamlin L, Picciano MF, Prentice A and Milner JA, Milk selenium of rural African women: influence of maternal nutrition, parity, and length of lactation. Am J Clin Nutr 51:220-224 (1990).
Kumpulainen J, Salmenperä L, Siimes M, Koivistoinen P and Perheentupa J, Selenium status of exclusively breast-fed infants as influenced by maternal organic or inorganic selenium supplementation. Am J Clin Nutr 42:829-835 (1985).
Shi YD, Sun GQ, Zhang ZG, Deng X, Kang XH, Liu ZD et al., The chemical composition of human milk from Inner Mongolia of China. Food Chem 127:1193-1198 (2011).
Su MY, Jia HX, Chen WL, Qi XY, Liu CP and Liu ZM, Macronutrient and micronutrient composition of breast milk from women of different ages and dietary habits in Shanghai area. Int Dairy J 85:27-34 (2018).
Wang Y, Yu JH, Liu Y, Luo J, Zheng XB, Zhang X et al., Determination of amino acid content in human coagulation factor VII by HPLC with pre-column derivation. Chin J Biol 32:1402-6+10 (2019).
Denne SC and Kalhan SC, Leucine metabolism in human newborns. Am J Physiol 253:E608-E615 (1987).
Hu XY, Liu XH, Zhang L, Zhou L and Cao J, Association between pre -pregnancy body mass index and maternal weight gain and birth weight. Chin J Obs 5:33-36 (2009).
Fu CH and Zhang QP, Effects of lifestyle interventions on weight of pregnant women and newborns with gestational diabetes. Jiangxi Med J 52:433-435 (2017).
Wu QC and Li SY, Effect of pre-pregnancy body mass index and maternal weight gain on pregnancy outcome. Chin J Perinat Med 4:81-84 (2001).
Kalhan SC and Parimi PS, Transamination of leucine and nitrogen accretion in human pregnancy and the newborn infant. J Nutr 136:281S-287S (2006).
Baldeón ME, Zertuche F, Flores N and Fornasini M, Free amino acid content in human milk is associated with infant gender and weight gain during the first four months of lactation. Nutrients 11:2239 (2019).
Heine W, Is motherʼs milk the most suitable food for very low birth weight infants? Early Hum Dev 29:345-350 (1992).
Kaufman S, The phenylalanine hydroxylating system from mammalian liver. Adv Enzymol 35:245-319 (1971).
Craine JE, Hall ES and Kaufman S, The isolation and characterization of dihydropteridine reductase from sheep liver. J Biol Chem 247:6082-6091 (1972).
Kilani RA, Cole FS and Bier DM, Phenylalanine hydroxylase activity in preterm infants: is tyrosine a conditionally essential amino acid? Am J Clin Nutr 61:1218-1223 (1995).
Widaman KF and Azen C, Relation of prenatal phenylalanine exposure to infant and childhood cognitive outcomes: results from the international maternal PKU collaborative study. Pediatrics 112:1537-1543 (2003).
Snyderman SE, Boyer A, Roitman E, Holt LE and Prose PH, The histidine requirement of the infant. Pediatrics 31:786-801 (1963).
Wang Q and Li GH, Associations between third trimester gestational weight gain, maternal lipid profile & prepregnancy body mass index and neonatal birth weight in pregnant women with normal glucose tolerance. Chin J Fam Plan 24:818-823 (2016).
Lv P, Zhou ML, Zhang ZJ and Chen DQ, The relationship between weight gain in different trimesters of gestation and neonatal birth weight. Prog Obstet Gynecol 26:362-365 (2017).
Song GY, Wang BB, Zhang S, Na Q and Song WW, Effect of gestational weight gain on the correlation between maternal lipid level and newborn body size in the women in late pregnancy. Chin J Pract Gynecol Obstet 32:576-579 (2016).
Liu JH, Li YZ, Ye YJ, Tang YZ and Yu J, Content and dynamic changes of free amino acids in human milk. Acta Nutr Sinica 14:171-175 (1992).
Carlson S, Human milk nonprotein nitrogen: occurrence and possible functions. Adv Pediatr 32:43-70 (1985).
Shenoy V, Roig J, Kubilis P and Neu J, Characterization of glutaminase in the developing rat small intestine. J Nutr. 126:1121S-1130S (1996).
Dorea JG, Calcium and phosphorus in human milk. Nutr Res 19:709-739 (1999).
Dawodu A, Zalla L, Woo JG, Herbers PM, Davidson BS, Heubi JE et al., Heightened attention to supplementation is needed to improve the vitamin D status of breastfeeding mothers and infants when sunshine exposure is restricted. Matern Child Nutr 10:383-397 (2014).
Pettifor J, Vitamin D &/or calcium deficiency rickets in infants & children: a global perspective. Indian J Med Res 127:245-249 (2008).
Camara-Martos F and Amaro-López M, Influence of dietary factors on calcium bioavailability. Biol Trace Elem Res 89:43-52 (2002).
Yoneyama K, Goto I and Nagata H, Relationship between volume and concentrations of various components of breast milk in early and 2-6 months lactation. Jpn J Public Health 41:157-164 (1994).
Yoneyama K, Goto I, Nagata H and Ikeda J, Effects of maternal food intake on the total protein, fat, lactose and calcium concentrations in human milk. Jpn J Public Health. 41:507-517 (1994).
YONEYAMA K, IKEDA J and NAGATA H, Interrelations of the calcium concentration in breast milk with maternal intake of cowʼs milk and milk products, bone resorption and bone mineral density during lactation. Jpn J Hyg 51:770-779 (1997).
Prentice A, Jarjou L, Cole TJ, Stirling DM, Dibba B and Fairweather-Tait S, Calcium requirements of lactating Gambian mothers: effects of a calcium supplement on breast-milk calcium concentration, maternal bone mineral content, and urinary calcium excretion. Am J Clin Nutr 62:58-67 (1995).
Kalkwarf HJ, Specker BL, Bianchi DC, Ranz J and Ho M, The effect of calcium supplementation on bone density during lactation and after weaning. N Engl J Med 337:523-528 (1997).
Prentice A, Parsons TJ and Cole TJ, Uncritical use of bone mineral density in absorptiometry may lead to size-related artifacts in the identification of bone mineral determinants. Am J Clin Nutr 60:837-842 (1994).
Prentice A, Yan L, Jarjou L, Dibba B, Laskey M, Stirling D et al., Vitamin D status does not influence the breast-milk calcium concentration of lactating mothers accustomed to a low calcium intake. Acta Paediatr 86:1006-1008 (1997).
Bae YJ and Kratzsch J, Vitamin D and calcium in the human breast milk. Best Pract Res Clin Endocrinol Metab 32:39-45 (2018).
Jarjou LM, Prentice A, Sawo Y, Laskey MA, Bennett J, Goldberg GR et al., Randomized, placebo-controlled, calcium supplementation study in pregnant Gambian women: effects on breast-milk calcium concentrations and infant birth weight, growth, and bone mineral accretion in the first year of life. Am J Clin Nutr 83:657-666 (2006).
Madanijah S, Rimbawan R, Briawan D, Zulaikhah Z, Andarwulan N, Nuraida L et al., Nutritional status of lactating women in Bogor district, Indonesia: cross-sectional dietary intake in three economic quintiles and comparison with pre-pregnant women. Br J Nutr. 116:S67-S74 (2016).
Kent JC, Arthur PG, Mitoulas LR and Hartmann PE, Why calcium in breastmilk is independent of maternal dietary calcium and vitamin D. Breastfeed Rev 17:5-11 (2009).
Lönnerdal B, Regulation of mineral and trace elements in human milk: exogenous and endogenous factors. Nutr Rev 58:223-229 (2000).
Mahdavi R, Taghipour S, Ostadrahimi A, Nikniaz L and Hezaveh SJG, A pilot study of synbiotic supplementation on breast milk mineral concentrations and growth of exclusively breast fed infants. J Trace Elem Med Biol 30:25-29 (2015).
Milner J, Sherman L and Picciano M, Distribution of selenium in human milk. Am J Clin Nutr 45:617-624 (1987).
Benemariya H, Robberecht H and Deelstra H, Copper, zinc and selenium concentrations in milk from middle-class women in Burundi (Africa) throughout the first 10 months of lactation. Sci Total Environ 164:161-174 (1995).
Bianchi M, Cruz A, Zanettti M and Dore J, Dietary intake of selenium and its concentration in breast milk. Biol Trace Elem Res 70:273-277 (1999).
Dorea JG, Selenium and breast-feeding. Br J Nutr 88:443-461 (2002).
Hannan MA, Faraji B, Tanguma J, Longoria N and Rodriguez R, Maternal milk concentration of zinc, iron, selenium, and iodine and its relationship to dietary intakes. Biol Trace Elem Res 127:6-15 (2009).
Environment and Endemic Disease Section IoG, Chinese Academy of Sciences, Geographical distribution of selenium content in human hair in Keshan-disease and non-disease zones in China. Acta Geogr Sinica 49:136-143 (1982).
Tang XX, Insufficient selenium intake - the soft underbelly of Chinese health. Med World.:19 (2004).
Li XL and Li XJ, Investigation of hair se level on healthy children and adults in Guangzhou region. Guangdong Trace Elem Sci 7:27-28 (2000).
Qu JG, Xu BX and Gong SC, Study on the speciation distribution and availability of selenium in different soils of Shanghai. Acta Pedologica Sinica 35:398-403 (1998).
Dong CY and Cao W, Investigation and analysis of per capita salt consumption in families of children aged 8-10 in Xincheng District, Xiʼan City. J Baotou Med Coll 30:28-30 (2014).
Chen JF, Liu H, Huang CP, Chen SC and Zhu XX, Analysis of Hangzhou City residentsʼsalt intake and influencing factors. Chin J Dis Control Prev 20:422-424 (2016).
Yang LL and Xi B, Secular trends in dietary sodium and potassium intakes in Chinese population, 2000-2015. Chin J Publ Health 33:1249-1253 (2017).
Lonnerdal B, Effects of milk and milk components on calcium, magnesium, and trace element absorption during infancy. Physiol Rev 77:643-669 (1997).
Casey CE, Hambidge KM and Neville MC, Studies in human lactation: zinc, copper, manganese and chromium in human milk in the first month of lactation. Am J Clin Nutr 41:1193-1200 (1985).
Ballard O and Morrow AL, Human milk composition: nutrients and bioactive factors. Pediatr Clin 60:49-74 (2013).
Zhang X, Ge WP, Xi ML, Zhang J, Yang L, Wu XY et al., Protein nutrition evaluation of infant formula with different base materials. Sci Technol Food Ind 13:43 (2019).
Hayat L, Al-Sughayer M and Afzal M, Fatty acid composition of human milk in Kuwaiti mothers. Comp Biochem Phys - B 124:261-267 (1999).
Al Mazroea A, Alharby MA, Almughathwai AA, Majed S, Al-Remaithi RM-HS, Alharbi AF et al., Comparison between nutritional values in cowʼs milk, and goat milk infant formulas. Int J Pharm Res Allied Sci 7:190-194 (2018).
Koletzko B, Baker S, Cleghorn G, Neto UF, Gopalan S, Hernell O et al., Global standard for the composition of infant formula: recommendations of an ESPGHAN coordinated international expert group. J Pediatr Gastr Nutr 41:584-599 (2005).