Cadmium-induced toxicity increases prolyl endopeptidase (PREP) expression in the rat testis.
Animals
Animals, Newborn
Animals, Suckling
Cadmium
/ toxicity
Cytoprotection
/ drug effects
Endocrine Disruptors
/ toxicity
Environmental Pollutants
/ toxicity
Female
Gene Expression Regulation, Developmental
/ drug effects
Gene Expression Regulation, Enzymologic
/ drug effects
Lactation
/ drug effects
Male
Pregnancy
Prenatal Exposure Delayed Effects
/ chemically induced
Prolyl Oligopeptidases
/ genetics
Rats
Spermatogenesis
/ drug effects
Testis
/ drug effects
Zinc
/ pharmacology
PREP
cadmium
endocrine disruptor
testis
zinc
Journal
Molecular reproduction and development
ISSN: 1098-2795
Titre abrégé: Mol Reprod Dev
Pays: United States
ID NLM: 8903333
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
22
01
2020
revised:
08
04
2020
accepted:
15
04
2020
pubmed:
25
4
2020
medline:
22
7
2021
entrez:
25
4
2020
Statut:
ppublish
Résumé
During the differentiation of the male gamete, there is a massive remodeling in the shape and architecture of all the cells of the seminiferous epithelium. The cytoskeleton, as well as many associated proteins with it, plays a pivotal role in this process. The testis is particularly susceptible to environmental pollutant, which can lead to injury and impairment of normal spermatozoa production. Cadmium (Cd) is one of the major chemical environmental toxicants in economically developed countries. Food and cigarettes are the main sources of exposure to this element. Here, the protective role of zinc (Zn) to prevent the testicular toxicity in male adult rats after prenatal and during lactation exposure to Cd has been assessed. Altered testicular histology at the interstitial and germinal levels was found, whereas Zn supply completely corrected Cd toxicity. Moreover, the effects of these metals on the testicular expression and localization of the protease prolyl endopeptidase (PREP) were evaluated. Interestingly, the results showed an increase of PREP messenger RNA and protein. Data were corroborated by immunofluorescence. This study raises the possibility of using PREP as a new fertility marker.
Substances chimiques
Endocrine Disruptors
0
Environmental Pollutants
0
Cadmium
00BH33GNGH
Prolyl Oligopeptidases
EC 3.4.21.26
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
565-573Informations de copyright
© 2020 Wiley Periodicals, Inc.
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