Stromal deactivation by CSF1: a new feature of the aggressive pancreatic cancer microenvironment.
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
06 05 2020
06 05 2020
Historique:
pubmed:
25
4
2020
medline:
27
10
2020
entrez:
25
4
2020
Statut:
ppublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with one of the poorest prognosis among all malignancies. The initiation and evolution of this kind of tumor depends on a complex interaction between cancer cells and the tumor microenvironment (TME). In an elegant study, Steins et al [1] used a combination of relevant disease models to show that mesenchymal subtype of PDAC shows a distinct deactivation of stellate cells in a CSF1-dependent fashion. This study shedding light on a new role for the stroma driving an aggressive PDAC subtypes shifts the current paradigm for the requirement of an activated TME to regulate PDAC growth and maintenance.
Identifiants
pubmed: 32329185
doi: 10.15252/embr.202050468
pmc: PMC7202212
doi:
Substances chimiques
Macrophage Colony-Stimulating Factor
81627-83-0
Types de publication
News
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
e50468Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2020 The Authors.
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