[Recent progress of positron radionuclide labeled small molecule inhibitors of prostate specific membrane antigen for PET/CT imaging of prostate cancer].
positron emission tomography/computed tomography
prostate cancer
prostate-specific membrane antigen
radiopharmaceuticals
Journal
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
ISSN: 1001-5515
Titre abrégé: Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
Pays: China
ID NLM: 9426398
Informations de publication
Date de publication:
25 Apr 2020
25 Apr 2020
Historique:
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
13
8
2020
Statut:
ppublish
Résumé
Prostate cancer is the most common tumor of the urinary system, and its mortality rate is second only to lung cancer. With the specific and high expression on the surface of prostate cancer cells, prostate-specific membrane antigen (PSMA) has been an ideal theranostic target of prostate cancer with great clinical significance and research value. Positron emission tomography/computed tomography (PET/CT), a new modality of molecular imaging combining functional metabolic information and anatomical structure, provides high diagnostic performance for cancer detection. This paper mainly reviewed recent progress of PSMA inhibitors labeled by positron-emitting radionuclides for early diagnosis, preoperative staging, response assessment, restaging and metastasis detection of prostate cancer. 前列腺癌是男性泌尿生殖系统中最为常见的肿瘤，其病死率仅次于肺癌。前列腺特异性膜抗原（PSMA）特异且高表达于前列腺癌细胞表面，因而成为前列腺癌诊断和治疗中较为理想的作用靶标，极具临床研究价值。正电子发射断层扫描/计算机断层扫描（PET/CT）是一种将功能代谢信息和解剖结构信息相结合的新型分子影像设备，对肿瘤诊断效能卓越。本文重点综述了国内外正电子放射性核素标记的靶向PSMA的小分子抑制剂在前列腺癌PET/CT的早期诊断、术前分期、疗效评估、复发和转移探测的研究进展，并对其发展前景进行展望。.
Autres résumés
Type: Publisher
(chi)
前列腺癌是男性泌尿生殖系统中最为常见的肿瘤，其病死率仅次于肺癌。前列腺特异性膜抗原（PSMA）特异且高表达于前列腺癌细胞表面，因而成为前列腺癌诊断和治疗中较为理想的作用靶标，极具临床研究价值。正电子发射断层扫描/计算机断层扫描（PET/CT）是一种将功能代谢信息和解剖结构信息相结合的新型分子影像设备，对肿瘤诊断效能卓越。本文重点综述了国内外正电子放射性核素标记的靶向PSMA的小分子抑制剂在前列腺癌PET/CT的早期诊断、术前分期、疗效评估、复发和转移探测的研究进展，并对其发展前景进行展望。.
Identifiants
pubmed: 32329272
doi: 10.7507/1001-5515.201911073
pmc: PMC9927617
doi:
Substances chimiques
Radioisotopes
0
KLK3 protein, human
EC 3.4.21.-
Kallikreins
EC 3.4.21.-
Prostate-Specific Antigen
EC 3.4.21.77
Types de publication
Journal Article
Review
Langues
chi
Sous-ensembles de citation
IM
Pagination
219-224Références
J Cell Biochem. 2004 Feb 15;91(3):528-39
pubmed: 14755683
Mol Imaging Biol. 2015 Aug;17(4):565-74
pubmed: 25896814
J Nucl Med. 2017 Mar;58(3):425-431
pubmed: 27789722
Hum Pathol. 2007 May;38(5):696-701
pubmed: 17320151
J Nucl Med. 2009 Dec;50(12):2042-8
pubmed: 19910433
Bioconjug Chem. 2012 Apr 18;23(4):688-97
pubmed: 22369515
Mol Pharm. 2013 Aug 5;10(8):2975-85
pubmed: 23768233
CA Cancer J Clin. 2016 Mar-Apr;66(2):115-32
pubmed: 26808342
Urology. 2003 Feb;61(2):463
pubmed: 12597980
Clin Cancer Res. 2011 Dec 15;17(24):7645-53
pubmed: 22042970
Prostate. 2008 Jun 15;68(9):955-64
pubmed: 18361407
Biochim Biophys Acta. 1998 Nov 26;1443(1-2):113-27
pubmed: 9838072
Eur J Nucl Med Mol Imaging. 2013 Apr;40(4):486-95
pubmed: 23179945
Bioconjug Chem. 2016 Jul 20;27(7):1655-62
pubmed: 27270097
Clin Cancer Res. 2008 May 15;14(10):3036-43
pubmed: 18483369
J Biol Chem. 1987 Oct 25;262(30):14498-506
pubmed: 3667587
J Nucl Med. 2018 Nov;59(11):1665-1671
pubmed: 29602821
Expert Rev Mol Diagn. 2016 Nov;16(11):1177-1188
pubmed: 27679869
J Nucl Med. 2018 Jul;59(7):1076-1080
pubmed: 29269569
CA Cancer J Clin. 2018 Jan;68(1):7-30
pubmed: 29313949
Eur J Nucl Med Mol Imaging. 2016 Jul;43(8):1410-7
pubmed: 26993315
J Nucl Med. 2012 Dec;53(12):1883-91
pubmed: 23203246
J Med Chem. 2003 May 8;46(10):1989-96
pubmed: 12723961
J Nucl Med. 2016 Jan;57(1):46-53
pubmed: 26493203
Drug Discov Today. 2007 Sep;12(17-18):767-76
pubmed: 17826690
Eur J Nucl Med Mol Imaging. 2017 Apr;44(4):678-688
pubmed: 27889802
Zhonghua Nan Ke Xue. 2005 Sep;11(9):693-6, 712
pubmed: 16209214
Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):749-53
pubmed: 8570628
Eur J Nucl Med Mol Imaging. 2017 Aug;44(8):1258-1268
pubmed: 28497198
Clin Cancer Res. 1997 Jan;3(1):81-5
pubmed: 9815541
Nucl Med Biol. 2015 Oct;42(10):780-7
pubmed: 26169882
Mol Imaging. 2002 Apr-Jun;1(2):96-101
pubmed: 12920850
Mol Imaging Biol. 2016 Jun;18(3):411-9
pubmed: 27080322