Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health.
Amidohydrolases
/ chemistry
Bacteria
/ enzymology
Bile Acids and Salts
/ metabolism
Cardiovascular Diseases
/ enzymology
Diabetes Mellitus, Type 2
/ enzymology
Gastrointestinal Diseases
/ enzymology
Gastrointestinal Microbiome
/ physiology
Gastrointestinal Tract
/ microbiology
Humans
Liver Diseases
/ enzymology
Metagenome
Metagenomics
Microbiota
/ physiology
Nervous System Diseases
/ enzymology
Phylogeny
Gut microbiome
bile acids
bile salt hydrolase
human health
metagenomic cohorts
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
02 09 2020
02 09 2020
Historique:
pubmed:
25
4
2020
medline:
29
6
2021
entrez:
25
4
2020
Statut:
ppublish
Résumé
Bile acid metabolism by the gut microbiome exerts both beneficial and harmful effects on host health. Microbial bile salt hydrolases (BSHs), which initiate bile acid metabolism, exhibit both positive and negative effects on host physiology. In this study, 5,790 BSH homologs were collected and classified into seven clusters based on a sequence similarity network. Next, the abundance and distribution of BSH in 380 metagenomes from healthy participants were analyzed. It was observed that different clusters occupied diverse ecological niches in the human microbiome and that the clusters with signal peptides were relatively abundant in the gut. Then, the association between BSH clusters and 12 human diseases was analyzed by comparing the abundances of BSH genes in patients (
Identifiants
pubmed: 32329665
doi: 10.1080/19490976.2020.1748261
pmc: PMC7524343
doi:
Substances chimiques
Bile Acids and Salts
0
Amidohydrolases
EC 3.5.-
choloylglycine hydrolase
EC 3.5.1.24
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1300-1313Références
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