Design, Synthesis, and Bioactivity of Cyclic Lipopeptide Antibiotics with Varied Polarity, Hydrophobicity, and Positive Charge Distribution.

Animals Anti-Bacterial Agents / pharmacology Hydrophobic and Hydrophilic Interactions Mice Microbial Sensitivity Tests Peptides, Cyclic / pharmacology Polymyxin B / pharmacology
Gram-negative “superbugs” bioactivity evaluation novel polymyxin analogs structure−activity relationship varied positive charges

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
10 07 2020
Historique:
pubmed: 25 4 2020
medline: 24 6 2021
entrez: 25 4 2020
Statut: ppublish

Résumé

Twenty-three polymyxin analogs with variations at nine amino acid positions were synthesized and assessed for antimicrobial activity and renal cytotoxicity. Compounds

Identifiants

DOI: 10.1021/acsinfecdis.0c00056 PMID: 32330004
pubmed: 32330004
doi: 10.1021/acsinfecdis.0c00056
doi:

Substances chimiques

Anti-Bacterial Agents 0
Peptides, Cyclic 0
Polymyxin B J2VZ07J96K

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1796-1806

Auteurs

A-Long Cui (AL)

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Xin-Xin Hu (XX)

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Yang Chen (Y)

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Jie Jin (J)

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Hong Yi (H)

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Xiu-Kun Wang (XK)

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Qi-Yang He (QY)

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Xue-Fu You (XF)

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Zhuo-Rong Li (ZR)

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
ORCID: 0000-0001-5748-7444

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Design, Synthesis, and Bioactivity of Cyclic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Design, Synthesis, and Bioactivity of Cyclic...
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › Design, Synthesis, and Bioactivity of Cyclic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Design, Synthesis, and Bioactivity of Cyclic...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Design, Synthesis, and Bioactivity of Cyclic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Design, Synthesis, and Bioactivity of Cyclic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Polymyxines › Polymyxine B › Design, Synthesis, and Bioactivity of Cyclic...