Persistent viral RNA positivity during the recovery period of a patient with SARS-CoV-2 infection.
SARS-CoV-2
coronavirus
saliva
virus shedding
Journal
Journal of medical virology
ISSN: 1096-9071
Titre abrégé: J Med Virol
Pays: United States
ID NLM: 7705876
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
03
04
2020
revised:
20
04
2020
accepted:
21
04
2020
pubmed:
25
4
2020
medline:
29
12
2020
entrez:
25
4
2020
Statut:
ppublish
Résumé
As an emerging infectious disease, the clinical course and virological course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain to be further investigated. In this case report, we described a case of SARS-CoV-2 infection with the clinical course for more than 2 months. This patient had recovered from pneumonia after treatment. The viral RNA of throat swabs became negative and the viral-specific antibodies were produced during the recovery period. However, the viral RNA reappeared and additionally persisted in throat swabs for more than 40 days. In addition, the viral RNA was detected in multiple types of specimens with extremely high titers in the saliva. In conclusion, these findings indicate that SARS-CoV-2 can cause a long clinical course. The coexistence of viral RNA and viral-specific antibodies may imply an immune evasion of SARS-CoV-2 from the host's immune system.
Identifiants
pubmed: 32330293
doi: 10.1002/jmv.25940
pmc: PMC7264719
doi:
Substances chimiques
Biomarkers
0
RNA, Viral
0
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1681-1683Subventions
Organisme : Basic Science and Advanced Technology Foundation of Chongqing Science and Technology Commission
ID : cstc2016jcyjA0158
Pays : International
Organisme : National Natural Science Foundation of China
ID : 81670530
Pays : International
Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Cell. 2009 Jul 10;138(1):30-50
pubmed: 19596234
Int J Infect Dis. 2020 Apr;93:297-299
pubmed: 32147538
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
Med Microbiol Immunol. 2008 Jun;197(2):205-13
pubmed: 18259775
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
Nature. 2020 May;581(7809):465-469
pubmed: 32235945
J Med Virol. 2020 Sep;92(9):1681-1683
pubmed: 32330293
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Lancet. 2020 Feb 15;395(10223):507-513
pubmed: 32007143
J Med Virol. 2020 Jul;92(7):909-914
pubmed: 32222992
J Virol. 2011 Apr;85(8):4025-30
pubmed: 21289121
JAMA. 2020 May 12;323(18):1843-1844
pubmed: 32159775
Emerg Microbes Infect. 2020 Dec;9(1):386-389
pubmed: 32065057