Seek and hide: the manipulating interplay of measles virus with the innate immune system.
Journal
Current opinion in virology
ISSN: 1879-6265
Titre abrégé: Curr Opin Virol
Pays: Netherlands
ID NLM: 101560941
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
08
01
2020
revised:
02
03
2020
accepted:
05
03
2020
pubmed:
25
4
2020
medline:
4
6
2021
entrez:
25
4
2020
Statut:
ppublish
Résumé
The innate immune system is the first line of defense against infections with pathogens. It provides direct antiviral mechanisms to suppress the viral life cycle at multiple steps. Innate immune cells are specialized to recognize pathogen infections and activate and modulate adaptive immune responses through antigen presentation, co-stimulation and release of cytokines and chemokines. Measles virus, which causes long-lasting immunosuppression and immune-amnesia, primarily infects and replicates in innate and adaptive immune cells, such as dendritic cells, macrophages, T cells and B cells. To achieve efficient replication, measles virus has evolved multiple mechanisms to manipulate innate immune responses by both stimulation and blocking of specific signals necessary for antiviral immunity. This review will highlight our current knowledge in this and address open questions.
Identifiants
pubmed: 32330821
pii: S1879-6257(20)30010-9
doi: 10.1016/j.coviro.2020.03.001
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
18-30Subventions
Organisme : NCI NIH HHS
ID : T32 CA217836
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.