Extracellular vesicles as biomarkers in malignant pleural mesothelioma: A review.

Biomarkers Cell-Derived Microparticles Exosomes Extracellular Vesicles Humans Mesothelioma
Apoptotic bodies Biomarkers Exosomes Extracellular vesicles Mesothelioma Microvesicles Oncosomes

Journal

Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049

Informations de publication

Date de publication:
Jun 2020
Historique:
received: 03 02 2020
revised: 28 03 2020
accepted: 30 03 2020
pubmed: 25 4 2020
medline: 17 6 2020
entrez: 25 4 2020
Statut: ppublish

Résumé

Extracellular vesicles (EV) are secreted by all cells, including cancer cells, as a mode of intercellular transport and communication. The main types of EV known to date include exosomes, microvesicles and apoptotic bodies, as well as oncosomes and large oncosomes, which are specific to cancer cells. These different EV populations carry specific cargo from one cell to another to stimulate a specific response. They can be found in all body fluids and can be detected in liquid biopsies. EV released from mesothelioma cells can reveal important information about the molecules and signalling pathways involved in the development and progression of the tumour. The presence of tumour-derived EV in circulating body fluids makes them potential novel biomarkers for early diagnosis, prognostication and surveillance of cancer. In this review, we explore the characteristics and functional roles of EV reported in the literature, with a focus on their role in malignant pleural mesothelioma.

Identifiants

DOI: 10.1016/j.critrevonc.2020.102949 PMID: 32330840
pubmed: 32330840
pii: S1040-8428(20)30087-1
doi: 10.1016/j.critrevonc.2020.102949
pii:
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102949

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare no conflicts of interest relevant to this manuscript.

Auteurs

Tamkin Ahmadzada (T)

Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia. Electronic address: tahm4852@uni.sydney.edu.au.

Steven Kao (S)

Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia; Chris O'Brien Lifehouse, Sydney, NSW, Australia; Asbestos Diseases Research Institute (ADRI), Sydney, NSW, Australia.

Glen Reid (G)

Department of Pathology, University of Otago, Dunedin, New Zealand.

Stephen Clarke (S)

Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia; Department of Medical Oncology, Royal North Shore Hospital, Sydney, NSW, Australia.

Georges E Grau (GE)

Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia; Vascular Immunology Unit, Department of Pathology, School of Medical Sciences, The University of Sydney, Camperdown, NSW, Australia.

Elham Hosseini-Beheshti (E)

Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia; Vascular Immunology Unit, Department of Pathology, School of Medical Sciences, The University of Sydney, Camperdown, NSW, Australia. Electronic address: Elham.beheshti@sydney.edu.au.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Extracellular vesicles as biomarkers in...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Microparticules membranaires › Extracellular vesicles as biomarkers in...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Exosomes › Extracellular vesicles as biomarkers in...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Extracellular vesicles as biomarkers in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Extracellular vesicles as biomarkers in...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs mésotheliales › Mésothéliome › Extracellular vesicles as biomarkers in...