A statistical comparison of reproducibility in current pediatric two-dimensional echocardiographic nomograms.
Adolescent
Child
Child, Preschool
Coronary Vessels
/ physiology
Decision Making
Echocardiography
/ methods
Female
Humans
Infant
Infant, Newborn
Italy
Linear Models
Male
Mitral Valve
/ physiology
Models, Statistical
Multivariate Analysis
Nomograms
Nonlinear Dynamics
Reference Values
Reproducibility of Results
Retrospective Studies
Tricuspid Valve
/ physiology
United States
Young Adult
Journal
Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
05
12
2019
accepted:
30
03
2020
revised:
13
03
2020
pubmed:
25
4
2020
medline:
15
1
2022
entrez:
25
4
2020
Statut:
ppublish
Résumé
The aim of this study is to compare new pediatric nomograms for clinical parameters from 2D echocardiography. 2D pediatric echocardiographic parameters from four recent nomograms were used for statistical analysis. To assess the accuracy of the predictive models from each study, namely multivariate, linear, and nonlinear regression, mean values and 5th and 95th percentiles (μ ± 1.65σ) were calculated. A Z-score calculator was created. Mean values and 5th and 95th percentiles have been provided for a range of BSA (0.15-2.20 m The two most recent echocardiographic nomograms were observed to have the most statistically similar ranges of normality. Significant deviations in ranges of normality were observed at extremes of BSA. Echocardiographic nomograms for pediatric age are discordant. Comparison of current pediatric echocardiographic nomograms. A Z-score calculator was created. Clinical relevance of differences among nomograms is highlighted.
Sections du résumé
BACKGROUND
The aim of this study is to compare new pediatric nomograms for clinical parameters from 2D echocardiography.
METHODS
2D pediatric echocardiographic parameters from four recent nomograms were used for statistical analysis. To assess the accuracy of the predictive models from each study, namely multivariate, linear, and nonlinear regression, mean values and 5th and 95th percentiles (μ ± 1.65σ) were calculated. A Z-score calculator was created.
RESULTS
Mean values and 5th and 95th percentiles have been provided for a range of BSA (0.15-2.20 m
CONCLUSIONS
The two most recent echocardiographic nomograms were observed to have the most statistically similar ranges of normality. Significant deviations in ranges of normality were observed at extremes of BSA.
IMPACT
Echocardiographic nomograms for pediatric age are discordant. Comparison of current pediatric echocardiographic nomograms. A Z-score calculator was created. Clinical relevance of differences among nomograms is highlighted.
Identifiants
pubmed: 32330930
doi: 10.1038/s41390-020-0900-z
pii: 10.1038/s41390-020-0900-z
doi:
Types de publication
Comparative Study
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
579-590Références
Lopez, L. et al. Relationship of echocardiographic Z scores adjusted for body surface area to age, sex, race, and ethnicity: the pediatric heart network normal echocardiogram database. Circ. Cardiovasc. Imaging 10, e006979 (2017).
doi: 10.1161/CIRCIMAGING.117.006979
Cantinotti, M. et al. Nomograms for two-dimensional echocardiography derived valvular and arterial dimensions in Caucasian children. J. Cardiol. 69, 208–215 (2017).
doi: 10.1016/j.jjcc.2016.03.010
Gautier, M. et al. Nomograms for aortic root diameters in children using two-dimensional echocardiography. Am. J. Cardiol. 105, 888–894 (2010).
doi: 10.1016/j.amjcard.2009.11.040
Warren, A. E., Boyd, M. L., O’Connell, C. & Dodds, L. Dilatation of the ascending aorta in paediatric patients with bicuspid aortic valve: frequency, rate of progression and risk factors. Heart 92, 1496–1500 (2006).
doi: 10.1136/hrt.2005.081539
Gokhroo, R. K. et al. A pediatric echocardiographic Z-score nomogram for a developing country: Indian pediatric echocardiography study–The Z-score. Ann. Pediatr. Cardiol. 10, 31 (2017).
doi: 10.4103/0974-2069.197053
Cantinotti, M. et al. Pediatric echocardiographic nomograms: what has been done and what still needs to be done. Trends Cardiovasc. Med. 27, 336–349 (2017).
doi: 10.1016/j.tcm.2017.01.006
Cantinotti, M. et al. Echocardiographic nomograms for ventricular, valvular and arterial dimensions in Caucasian children with a special focus on neonates, infants and toddlers. J. Am. Soc. Echocardiogr. 27, 179–191 (2014).
doi: 10.1016/j.echo.2013.10.001
Mawad, W., Drolet, C., Dahdah, N. & Dallaire, F. A review and critique of the statistical methods used to generate reference values in pediatric echocardiography. J. Am. Soc. Echocardiogr. 26, 29–37 (2013).
doi: 10.1016/j.echo.2012.09.021
Cantinotti, M., Scalese, M., Molinaro, S., Murzi, B. & Passino, C. Limitations of current echocardiographic nomograms for left ventricular, valvular, and arterial dimensions in children: a critical review. J. Am. Soc. Echocardiogr. 25, 142–152 (2012).
doi: 10.1016/j.echo.2011.10.016
Sluysmans, T. & Colan, S. D. Theoretical and empirical derivation of cardiovascular allometric relationships in children. J. Appl. Physiol. 99, 445–457 (2005).
doi: 10.1152/japplphysiol.01144.2004
Daubeney, P. E. F. et al. Relationship of the dimension of cardiac structures to body size: an echocardiographic study in normal infants and children. Cardiol. Young 9, 402–410 (1999).
doi: 10.1017/S1047951100005217
Zilberman, M. V., Khoury, P. R. & Kimball, R. T. Two-dimensional echocardiographic valve measurements in healthy children: gender-specific differences. Pediatr. Cardiol. 26, 356–360 (2005).
doi: 10.1007/s00246-004-0736-z
Pettersen, M. D., Du, W., Skeens, M. E. & Humes, R. A. Regression equations for calculation of z scores of cardiac structures in a large cohort of healthy infants, children, and adolescents: an echocardiographic study. J. Am. Soc. Echocardiogr. 21, 922–934 (2008).
doi: 10.1016/j.echo.2008.02.006
Şişli, E. et al. Comparison between nomograms used to define pediatric aortic arch hypoplasia: retrospective evaluation among patients less than 1 year old with coarctation of the aorta. Pediatr. Cardiol. 40, 1190–1198 (2019).
doi: 10.1007/s00246-019-02130-2
Yao, G.-H. et al. Echocardiographic measurements in normal Chinese adults focusing on cardiac chambers and great arteries: a prospective, nationwide, and multicenter study. J. Am. Soc. Echocardiogr. 28, 570–579 (2015).
doi: 10.1016/j.echo.2015.01.022
Kou, S. et al. Echocardiographic reference ranges for normal cardiac chamber size: results from the NORRE study. Eur. Heart J. Cardiovasc. Imaging 15, 680–690 (2014).
doi: 10.1093/ehjci/jet284
Daimon, M. et al. Normal values of echocardiographic parameters in relation to age in a healthy Japanese population. Circ. J. 72, 1859–1866 (2008).
doi: 10.1253/circj.CJ-08-0171
Pfaffenberger, S. et al. Size matters! Impact of age, sex, height, and weight on the normal heart size. Circ. Cardiovasc. Imaging 6, 1073–1079 (2013).
doi: 10.1161/CIRCIMAGING.113.000690
Poppe, K. K. et al. Ethnic-specific normative reference values for echocardiographic LA and LV size, LV mass, and systolic function: the EchoNoRMAL Study. JACC Cardiovasc. Imaging 8, 656–665 (2015).
doi: 10.1016/j.jcmg.2015.02.014
Lopez, L. et al. Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the Pediatric Measurements Writing Group of the American Society of Echocardiography Pediatric and Congenital Heart Disease Council. J. Am. Soc. Echocardiogr. 23, 465–495 (2010).
doi: 10.1016/j.echo.2010.03.019