Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and NLRP3 Inflammasome Genes in Aged C57BL/6 Mouse Ovaries.
Korean ginseng extract
NLRP3 inflammasome
aging
ovary
oxidative stress response
subfertility
Journal
Foods (Basel, Switzerland)
ISSN: 2304-8158
Titre abrégé: Foods
Pays: Switzerland
ID NLM: 101670569
Informations de publication
Date de publication:
22 Apr 2020
22 Apr 2020
Historique:
received:
24
03
2020
revised:
10
04
2020
accepted:
13
04
2020
entrez:
26
4
2020
pubmed:
26
4
2020
medline:
26
4
2020
Statut:
epublish
Résumé
Female infertility and subfertility have been increasing in prevalence worldwide. One contributing factor is ovarian function, which is highly age-dependent. Korean red ginseng is widely used as an herbal medicine and has many beneficial properties. We aimed to determine the effect of the Korean red ginseng saponin fraction (KRGSF) on ovarian function in female C57BL/6 mice. Ovaries were isolated from 6- and 12-month-old female mice and treated with KRGSF, and then RNA was extracted and microarray analysis was performed. The expression of key genes was subsequently verified using quantitative RT-PCR. Aging markedly increased the expression of genes encoding oxidative stress factors and NLRP3 inflammasome components, but the expression of these genes was significantly reduced by KRGSF treatment. Thus, the reduction in ovarian health with age is associated with greater oxidative stress response and inflammation, but KRGSF treatment may limit these age-related changes.
Identifiants
pubmed: 32331214
pii: foods9040526
doi: 10.3390/foods9040526
pmc: PMC7231237
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Cell Death Differ. 2015 Nov;22(11):1837-45
pubmed: 25882048
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7915-22
pubmed: 8367443
Biomed Res Int. 2015;2015:767124
pubmed: 25705687
J Ginseng Res. 2019 Oct;43(4):589-599
pubmed: 31695565
J Ginseng Res. 2014 Jul;38(3):161-6
pubmed: 25378989
J Clin Biochem Nutr. 2013 Jul;53(1):15-20
pubmed: 23874065
J Agric Food Chem. 2005 Nov 2;53(22):8498-505
pubmed: 16248544
BJU Int. 2004 Sep;94(4):663-8
pubmed: 15329132
Science. 2002 May 10;296(5570):1029-31
pubmed: 12004104
Indian Heart J. 2016 Jan-Feb;68(1):19-27
pubmed: 26896262
Circ Res. 2008 Jul 3;103(1):e1-9
pubmed: 18535259
Front Cell Dev Biol. 2019 Oct 30;7:256
pubmed: 31750302
FASEB J. 2003 Jun;17(9):1183-5
pubmed: 12709402
Molecules. 2020 Feb 25;25(5):
pubmed: 32106493
J Ginseng Res. 2012 Jul;36(3):263-9
pubmed: 23717127
Panminerva Med. 1996 Dec;38(4):249-54
pubmed: 9063034
Oxid Med Cell Longev. 2016;2016:2183026
pubmed: 27127546
J Med Food. 2012 Nov;15(11):1015-23
pubmed: 23126662
J Ginseng Res. 2011 Sep;35(3):325-30
pubmed: 23717076
Sci Rep. 2020 Feb 7;10(1):2075
pubmed: 32034213
Tumour Biol. 2015 Feb;36(2):655-62
pubmed: 25283382
Nat Rev Immunol. 2019 Aug;19(8):477-489
pubmed: 31036962
Endocr Rev. 2009 Aug;30(5):465-93
pubmed: 19589949
Am J Chin Med. 2005;33(3):397-404
pubmed: 16047557
J Immunol Res. 2019 Jan 2;2019:8069898
pubmed: 30719458
Minerva Urol Nefrol. 2010 Sep;62(3):213-8
pubmed: 20940690
Int J Mol Sci. 2019 Jul 06;20(13):
pubmed: 31284572
J Ginseng Res. 2019 Apr;43(2):252-260
pubmed: 30976163
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3481-6
pubmed: 25733862
J Pineal Res. 2017 Oct;63(3):
pubmed: 28658519