Beneficial Effects of Melatonin on Apolipoprotein-E Knockout Mice by Morphological and
Adipose Tissue, Brown
/ metabolism
Animals
Aortitis
/ etiology
Apolipoproteins E
/ deficiency
Atherosclerosis
/ diagnostic imaging
Biomarkers
Cytokines
/ metabolism
Disease Models, Animal
Fluorescent Antibody Technique
Fluorodeoxyglucose F18
Humans
Macrophages
/ immunology
Melatonin
/ metabolism
Mice
Mice, Knockout
Molecular Imaging
/ methods
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
PET/CT
atherosclerosis
macrophage polarization
melatonin
molecular imaging
perivascular brown adipose tissue
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Apr 2020
22 Apr 2020
Historique:
received:
23
03
2020
revised:
16
04
2020
accepted:
21
04
2020
entrez:
26
4
2020
pubmed:
26
4
2020
medline:
22
1
2021
Statut:
epublish
Résumé
Atherosclerosis represents one of the main risk factors for the development of cardiovascular diseases. Their etiologies have been studied in recent years in order to better define therapeutic targets for intervention and to identify diagnostic methods. Two different subtypes of macrophages, M1 and M2, have been described in physiological conditions. They can also be found in the atherosclerotic process, where they both have opposite roles in disease progression. Perivascular brown adipose tissue is also involved in inflammation and endothelial damage. In this work, we provide insights into the protective role of melatonin in the atherosclerotic process by morphological and
Identifiants
pubmed: 32331251
pii: ijms21082920
doi: 10.3390/ijms21082920
pmc: PMC7216051
pii:
doi:
Substances chimiques
Apolipoproteins E
0
Biomarkers
0
Cytokines
0
Radiopharmaceuticals
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Melatonin
JL5DK93RCL
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R21EB018055
Pays : United States
Organisme : Università degli Studi di Brescia
ID : ex-60%
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