RSV Reprograms the CDK9•BRD4 Chromatin Remodeling Complex to Couple Innate Inflammation to Airway Remodeling.
Airway Remodeling
Biomarkers
Cell Cycle Proteins
Chromatin Assembly and Disassembly
Cyclin-Dependent Kinase 9
Disease Susceptibility
Gene Expression Profiling
Gene Expression Regulation
Host-Pathogen Interactions
Humans
Immunity, Innate
Paracrine Communication
Respiratory Mucosa
/ immunology
Respiratory Syncytial Virus Infections
/ etiology
Respiratory Syncytial Virus, Human
/ physiology
Signal Transduction
Transcription Factors
Virus Replication
Airway remodeling
bromodomain containing protein 4 (BRD4)
cyclin dependent kinase 9 (CDK9)
epigenetics
mesenchymal transition
myofibroblast
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
22 04 2020
22 04 2020
Historique:
received:
27
03
2020
revised:
17
04
2020
accepted:
19
04
2020
entrez:
26
4
2020
pubmed:
26
4
2020
medline:
20
2
2021
Statut:
epublish
Résumé
Respiratory syncytial virus infection is responsible for seasonal upper and lower respiratory tract infections worldwide, causing substantial morbidity. Self-inoculation of the virus into the nasopharynx results in epithelial replication and distal spread into the lower respiratory tract. Here, respiratory syncytial virus (RSV) activates sentinel cells important in the host inflammatory response, resulting in epithelial-derived cytokine and interferon (IFN) expression resulting in neutrophilia, whose intensity is associated with disease severity. I will synthesize key findings describing how RSV replication activates intracellular NFκB and IRF signaling cascades controlling the innate immune response (IIR). Recent studies have implicated a central role for
Identifiants
pubmed: 32331282
pii: v12040472
doi: 10.3390/v12040472
pmc: PMC7232410
pii:
doi:
Substances chimiques
BRD4 protein, human
0
Biomarkers
0
Cell Cycle Proteins
0
Transcription Factors
0
CDK9 protein, human
EC 2.7.11.22
Cyclin-Dependent Kinase 9
EC 2.7.11.22
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : P01 AI062885
Pays : United States
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