Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors.

Antifungal Agents / chemistry Binding Sites Candida / drug effects Carbonic Anhydrase Inhibitors / chemistry Catalytic Domain Drug Development Humans Microbial Sensitivity Tests Molecular Conformation Molecular Docking Simulation Molecular Dynamics Simulation Molecular Structure Protein Binding Structure-Activity Relationship
4-thiazolidinones CYP51a1 CgNce103 antifungal activity carbonic anhydrases lanosterol 14α-demethylase molecular modelling studies

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
22 Apr 2020
Historique:
received: 27 03 2020
revised: 17 04 2020
accepted: 20 04 2020
entrez: 26 4 2020
pubmed: 26 4 2020
medline: 26 1 2021
Statut: epublish

Résumé

In our efforts to find new and selective thiazolidinone-based anti-

Identifiants

DOI: 10.3390/ijms21082960 PMID: 32331447 PMC: PMC7215574
pubmed: 32331447
pii: ijms21082960
doi: 10.3390/ijms21082960
pmc: PMC7215574
pii:
doi:

Substances chimiques

Antifungal Agents 0
Carbonic Anhydrase Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Research Fund of the Istanbul University (Project Number BEK 24737).
ID : BEK 24737

Références

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Auteurs

Özlen Güzel-Akdemir (Ö)

Istanbul University, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 34116 Istanbul, Turkey.
ORCID: 0000-0003-3680-1945

Simone Carradori (S)

Dipartimento di Farmacia, "G. d'Annunzio" University of Chieti-Pescara, Via dei vestini 31, 66100 Chieti, Italy.
ORCID: 0000-0002-8698-9440

Rossella Grande (R)

Dipartimento di Farmacia, "G. d'Annunzio" University of Chieti-Pescara, Via dei vestini 31, 66100 Chieti, Italy.
ORCID: 0000-0002-8432-6889

Kübra Demir-Yazıcı (K)

Istanbul University, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, 34116 Istanbul, Turkey.

Andrea Angeli (A)

Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
Centre of Advanced Research in Bionanoconjugates and Biopolymers Department, "Petru Poni" Institute of Macromolecular Chemistry, 700487 Iasi, Romania.
ORCID: 0000-0002-1470-7192

Claudiu T Supuran (CT)

Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, Università degli Studi di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino (Florence), Italy.
ORCID: 0000-0003-4262-0323

Atilla Akdemir (A)

Bezmialem Vakif University, Computer-aided drug discovery laboratory, Department of Pharmacology, Faculty of Pharmacy, 34093 Istanbul, Turkey.
ORCID: 0000-0001-8416-0471

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Candida › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de l'anhydrase carbonique › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Domaine catalytique › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Development of Thiazolidinones as Fungal...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Development of Thiazolidinones as Fungal...