Endothelial Cells, First Target of Drug Delivery Using Microbubble-Assisted Ultrasound.
Drug delivery
Endothelial barrier
Endothelial cells
Endothelial membrane
Microbubble
Permeability
Ultrasound
Vascular effects
Journal
Ultrasound in medicine & biology
ISSN: 1879-291X
Titre abrégé: Ultrasound Med Biol
Pays: England
ID NLM: 0410553
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
28
10
2019
revised:
12
03
2020
accepted:
13
03
2020
pubmed:
26
4
2020
medline:
20
8
2021
entrez:
26
4
2020
Statut:
ppublish
Résumé
Microbubble-assisted ultrasound has emerged as a promising method for local drug delivery. Microbubbles are intravenously injected and locally activated by ultrasound, thus increasing the permeability of vascular endothelium for facilitating extravasation and drug uptake into the treated tissue. Thereby, endothelial cells are the first target of the effects of ultrasound-driven microbubbles. In this review, the in vitro and in vivo bioeffects of this method on endothelial cells are described and discussed, including aspects on the permeabilization of biologic barriers (endothelial cell plasma membranes and endothelial barriers), the restoration of their integrity, the molecular and cellular mechanisms involved in both these processes, and the resulting intracellular and intercellular consequences. Finally, the influence of the acoustic settings, microbubble parameters, treatment schedules and flow parameters on these bioeffects are also reviewed.
Identifiants
pubmed: 32331799
pii: S0301-5629(20)30129-0
doi: 10.1016/j.ultrasmedbio.2020.03.013
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1565-1583Informations de copyright
Copyright © 2020 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.