Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2.

3T3 Cells Animals Bone Morphogenetic Protein 2 / administration & dosage Cell Differentiation / drug effects Cells, Cultured Enhancer of Zeste Homolog 2 Protein / antagonists & inhibitors Humans Indoles / administration & dosage Mice Osteoblasts / drug effects Osteogenesis / drug effects Pyridones / administration & dosage
BMP2 Ezh2 bone development bone morphogenetic protein (BMP) chromatin regulation enhancer of zeste homolog epigenetics histone methylation mesenchymal stem cells (MSCs) methyltransferase osteoblast osteogenesis

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
05 06 2020
Historique:
received: 29 10 2019
revised: 22 04 2020
pubmed: 26 4 2020
medline: 29 12 2020
entrez: 26 4 2020
Statut: ppublish

Résumé

Bone-stimulatory therapeutics include bone morphogenetic proteins (

Identifiants

DOI: 10.1074/jbc.RA119.011685 PMID: 32332097 PMC: PMC7278362
pubmed: 32332097
pii: S0021-9258(17)49430-0
doi: 10.1074/jbc.RA119.011685
pmc: PMC7278362
doi:

Substances chimiques

BMP2 protein, human 0
Bmp2 protein, mouse 0
Bone Morphogenetic Protein 2 0
GSK-2816126 0
Indoles 0
Pyridones 0
Enhancer of Zeste Homolog 2 Protein EC 2.1.1.43

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7877-7893

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR049069
Pays : United States

Informations de copyright

© 2020 Dudakovic et al.

Déclaration de conflit d'intérêts

Conflict of interest—A. N. L. receives research support from Zimmer Biomet, Medtronic, and is an unpaid consultant for Globus.

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Auteurs

Amel Dudakovic (A)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Department of Biochemistry & Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.

Rebekah M Samsonraj (RM)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Christopher R Paradise (CR)

Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Center for Regenerative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
ORCID: 0000-0002-5882-709X

Catalina Galeano-Garces (C)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
ORCID: 0000-0003-1882-6858

Merel O Mol (MO)

Department of Orthopedic Surgery, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Daniela Galeano-Garces (D)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
ORCID: 0000-0003-0954-6352

Pengfei Zan (P)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Department of Orthopedic Surgery, School of Medicine, Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
Department of Orthopedic Surgery, School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.

M Lizeth Galvan (ML)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Mario Hevesi (M)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
ORCID: 0000-0001-6208-878X

Oksana Pichurin (O)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Roman Thaler (R)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Dana L Begun (DL)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Peter Kloen (P)

Department of Orthopedic Surgery, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Marcel Karperien (M)

Department of Developmental BioEngineering, University of Twente, Enschede, The Netherlands.

A Noelle Larson (AN)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Jennifer J Westendorf (JJ)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Department of Biochemistry & Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.
ORCID: 0000-0002-4464-6108

Simon M Cool (SM)

Glycotherapeutics Group, Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore.
Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Andre J van Wijnen (AJ)

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA vanwijnen.andre@mayo.edu.
Department of Biochemistry & Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.
ORCID: 0000-0002-4458-0946

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Cellules 3T3 › Inhibition of the epigenetic suppressor EZH2...
questionsmedicales.fr › Eucaryotes › Animaux › Inhibition of the epigenetic suppressor EZH2...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Protéines morphogénétiques osseuses › Protéine morphogénétique osseuse de type 2 › Inhibition of the epigenetic suppressor EZH2...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Inhibition of the epigenetic suppressor EZH2...
questionsmedicales.fr › Cellules › Cellules cultivées › Inhibition of the epigenetic suppressor EZH2...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Protéines du groupe Polycomb › Complexe répresseur Polycomb-2 › Protéine-2 homologue de l'activateur de Zeste › Inhibition of the epigenetic suppressor EZH2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Inhibition of the epigenetic suppressor EZH2...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Inhibition of the epigenetic suppressor EZH2...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Inhibition of the epigenetic suppressor EZH2...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Inhibition of the epigenetic suppressor EZH2...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Inhibition of the epigenetic suppressor EZH2...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Pyridones › Inhibition of the epigenetic suppressor EZH2...