CXCR4-Targeted PET Imaging of Central Nervous System B-Cell Lymphoma.

Aged Aged, 80 and over Central Nervous System Neoplasms / diagnostic imaging Coordination Complexes Female Gallium Radioisotopes Humans Lymphoma, B-Cell / diagnostic imaging Male Middle Aged Peptides, Cyclic Receptors, CXCR4 / metabolism Treatment Outcome
CXCR4 MRI PET central nervous system lymphoma in vivo imaging

Journal

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410

Informations de publication

Date de publication:
12 2020
Historique:
received: 05 01 2020
accepted: 19 03 2020
pubmed: 26 4 2020
medline: 6 3 2021
entrez: 26 4 2020
Statut: ppublish

Résumé

C-X-C chemokine receptor 4 (CXCR4) is a transmembrane chemokine receptor involved in growth, survival, and dissemination of cancer, including aggressive B-cell lymphoma. MRI is the standard imaging technology for central nervous system (CNS) involvement of B-cell lymphoma and provides high sensitivity but moderate specificity. Therefore, novel molecular and functional imaging strategies are urgently required.

Identifiants

DOI: 10.2967/jnumed.120.241703 PMID: 32332145
pubmed: 32332145
pii: jnumed.120.241703
doi: 10.2967/jnumed.120.241703
doi:

Substances chimiques

68Ga-pentixafor 0
CXCR4 protein, human 0
Coordination Complexes 0
Gallium Radioisotopes 0
Peptides, Cyclic 0
Receptors, CXCR4 0
Gallium-68 98B30EPP5S

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1765-1771

Informations de copyright

© 2020 by the Society of Nuclear Medicine and Molecular Imaging.

Auteurs

Peter Herhaus (P)

Internal Medicine III, School of Medicine, Technische Universität München, Munich, Germany.

Jana Lipkova (J)

Department of Neuroradiology, School of Medicine, Technische Universität München, Munich, Germany.

Felicitas Lammer (F)

Department of Hematology, Oncology, and Tumor Immunology (Campus Benjamin Franklin), Charité-Universitätsmedizin Berlin, Berlin, Germany.

Igor Yakushev (I)

Department of Nuclear Medicine, School of Medicine, Technische Universität München, Munich, Germany.

Tibor Vag (T)

Department of Nuclear Medicine, School of Medicine, Technische Universität München, Munich, Germany.

Julia Slotta-Huspenina (J)

Institute of Pathology, Technische Universität München, Munich, Germany.

Stefan Habringer (S)

Department of Hematology, Oncology, and Tumor Immunology (Campus Benjamin Franklin), Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Berlin, Germany.

Constantin Lapa (C)

Department of Nuclear Medicine, Universitätsklinikum Würzburg, Würzburg, Germany.
Department of Nuclear Medicine, University Hospital Augsburg, Augsburg, Germany.

Tobias Pukrop (T)

Internal Medicine III, Universitätsklinikum Regensburg, Regensburg, Germany.

Dirk Hellwig (D)

Department of Nuclear Medicine, Universitätsklinikum Regensburg, Regensburg, Germany.

Benedikt Wiestler (B)

Department of Neuroradiology, School of Medicine, Technische Universität München, Munich, Germany.

Andreas K Buck (AK)

Department of Nuclear Medicine, Universitätsklinikum Würzburg, Würzburg, Germany.

Martina Deckert (M)

Insitute of Neuropathology, Faculty of Medicine, University of Cologne, and University Hospital Cologne, Cologne, Germany.

Hans-Jürgen Wester (HJ)

Institute of Pharmaceutical Radiochemistry, Technische Universität München, Munich, Germany.

Florian Bassermann (F)

Internal Medicine III, School of Medicine, Technische Universität München, Munich, Germany.

Markus Schwaiger (M)

Department of Nuclear Medicine, School of Medicine, Technische Universität München, Munich, Germany.

Wolfgang Weber (W)

Department of Neuroradiology, School of Medicine, Technische Universität München, Munich, Germany.

Björn Menze (B)

Informatics Department, Technische Universität München, Munich, Germany.

Ulrich Keller (U)

Internal Medicine III, School of Medicine, Technische Universität München, Munich, Germany ulrich.keller@charite.de.
Department of Hematology, Oncology, and Tumor Immunology (Campus Benjamin Franklin), Charité-Universitätsmedizin Berlin, Berlin, Germany.
Max Delbrück Center for Molecular Medicine, Berlin, Germany; and.
German Cancer Research Center and German Cancer Consortium, Heidelberg, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › CXCR4-Targeted PET Imaging of Central Nervous...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › CXCR4-Targeted PET Imaging of Central Nervous...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › CXCR4-Targeted PET Imaging of Central Nervous...
questionsmedicales.fr › Composés chimiques organiques › Complexes de coordination › CXCR4-Targeted PET Imaging of Central Nervous...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Gallium › Isotopes du gallium › Radio-isotopes du gallium › CXCR4-Targeted PET Imaging of Central Nervous...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CXCR4-Targeted PET Imaging of Central Nervous...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome B › CXCR4-Targeted PET Imaging of Central Nervous...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › CXCR4-Targeted PET Imaging of Central Nervous...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › CXCR4-Targeted PET Imaging of Central Nervous...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Récepteurs CXCR4 › CXCR4-Targeted PET Imaging of Central Nervous...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › CXCR4-Targeted PET Imaging of Central Nervous...