Diabetes mellitus contributes to carbamazepine resistance in patient with trigeminal neuralgia.
Carbamazepine
Diabetes mellitus
Drug resistance
Trigeminal neuralgia
Journal
Neurosurgical review
ISSN: 1437-2320
Titre abrégé: Neurosurg Rev
Pays: Germany
ID NLM: 7908181
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
11
02
2020
accepted:
14
04
2020
revised:
08
04
2020
pubmed:
26
4
2020
medline:
16
6
2021
entrez:
26
4
2020
Statut:
ppublish
Résumé
To determine whether diabetes mellitus (DM) contributes to the drug resistance of carbamazepine (CBZ), we investigated the correlation between the blood glucose status and the CBZ resistance condition in patients with trigeminal neuralgia (TN). A total of 155 TN patients treated with the CBZ monotherapy were selected at Shanghai General Hospital and Shanghai Xinhua Hospital from September 2018 to January 2020. Among them, 15 were diagnosed with DM. Patients' CBZ resistance levels were evaluated according to progression-free survival. We utilized ordered multiple classification logistic regression to determine the dominant factors leading to CBZ resistance. We analyzed the correlation between hemoglobin A1c (HbA1c) and progression-free survival using the Pearson correlation analysis. The regression analysis showed that DM was the only factor affecting CBZ resistance (p = 0.035; OR = 0.327; 95% CI, 0.115-0.926). Progression-free survival was 28.5 ± 21.2 months in the DM group and 66.0 ± 33.2 months in the non-DM group. The concentration of HbA1c in the blood was negatively correlated with progression-free survival (r = - 0.197; p = 0.014). This study shows that blood glucose status is a significant factor contributing to the CBZ resistance in the treatment of TN. The progression-free survival of patients is affected by the status of DM and blood HbAlc levels.
Identifiants
pubmed: 32333283
doi: 10.1007/s10143-020-01304-4
pii: 10.1007/s10143-020-01304-4
doi:
Substances chimiques
Analgesics, Non-Narcotic
0
Carbamazepine
33CM23913M
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1119-1125Subventions
Organisme : National Natural Science Foundation of China
ID : No.81701359
Organisme : Natural Science Foundation of Shanghai
ID : 18ZR1430400
Organisme : the Cross Research Fund of Medicine and Engineering of Shanghai Jiaotong University
ID : No.YG2016QN32
Organisme : the Cross Research Fund of Medicine and Engineering of Shanghai Jiaotong University
ID : YG2019QNA67
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