Biomarkers of minimal residual disease in rituximab-treated patients with mixed cryoglobulinemia.
HCV
IgM heavy/light chains
biomarkers
free light chains
minimal residual disease
mixed cryoglobulinemia
rituximab
vascular endothelial growth factor
Journal
Biotechnology and applied biochemistry
ISSN: 1470-8744
Titre abrégé: Biotechnol Appl Biochem
Pays: United States
ID NLM: 8609465
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
30
12
2019
accepted:
12
04
2020
pubmed:
26
4
2020
medline:
6
7
2021
entrez:
26
4
2020
Statut:
ppublish
Résumé
Hepatitis C virus (HCV) represents the major risk factor for mixed cryoglobulinemia (MC), a small-vessel vasculitis that may evolve into an overt B-cell non-Hodgkin's lymphoma. Here, we aimed to identify a biomarker signature for the early diagnosis of minimal residual disease (MRD). We assessed free light chains (FLCs), IgM k,and IgM λ heavy/light chain (HLC) pairs, and vascular endothelial growth factor (VEGF) in sera from 34 patients with MC vasculitis (32 HCV- and 2 HBV-related), treated with low-dose rituximab (RTX). FLCs and IgM HLCs were measured by turbidimetric assay; VEGF by an enzyme-linked immunosorbent assay. After RTX, the positive (complete + partial) clinical and laboratory responses were of 85.29% and 50%, respectively; in contrast, the mean levels of FLCs, IgM HLCs, and VEGF were substantially unaffected in most patients and still above the normal range. In those achieving a reduction of FLCs and IgM k and λ chains values within the range of normality, we found that post-treatment free λ chains and IgM k values correlated with clinical and laboratory response. Our results suggest that high levels of FLCs, IgM HLCs, and VEGF could represent the signature of "dormant" B cell clones' activity that could be very useful to identify MRD indicative of possible relapse or worsening outcome.
Substances chimiques
Biomarkers
0
Immunoglobulin M
0
Immunoglobulin kappa-Chains
0
Immunoglobulin lambda-Chains
0
VEGFA protein, human
0
Vascular Endothelial Growth Factor A
0
Rituximab
4F4X42SYQ6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
319-329Informations de copyright
© 2020 International Union of Biochemistry and Molecular Biology, Inc.
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