Fibrin fragment E potentiates TGF-β-induced myofibroblast activation and recruitment.

Animals Apoptosis / drug effects Cell Proliferation / drug effects Chemotaxis / drug effects Female Fibrin Fibrinogen Degradation Products / metabolism Fibrosis Humans Integrin alphaVbeta3 / metabolism Male Membrane Proteins / metabolism Mice, Inbred C57BL Myofibroblasts / drug effects Protein Binding / drug effects Rats Subcutaneous Tissue / drug effects Toll-Like Receptor 4 / metabolism Transforming Growth Factor beta / pharmacology
Fibrinolysis Fibroblasts Fibrosis Inflammation Wound healing

Journal

Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683

Informations de publication

Date de publication:
08 2020
Historique:
received: 11 12 2019
revised: 19 04 2020
accepted: 20 04 2020
pubmed: 26 4 2020
medline: 4 8 2021
entrez: 26 4 2020
Statut: ppublish

Résumé

Fibrin is an essential constituent of the coagulation cascade, and the formation of hemostatic fibrin clots is central to wound healing. Fibrin clots are over time degraded into fibrin degradation products as the injured tissue is replaced by granulation tissue. Our goal was to study the role of the fibrin degradation product fragment E (FnE) in fibroblast activation and migration. We present evidence that FnE is a chemoattractant for fibroblasts and that FnE can potentiate TGF-β-induced myofibroblast formation. FnE forms a stable complex with α

Identifiants

DOI: 10.1016/j.cellsig.2020.109661 PMID: 32334027
pubmed: 32334027
pii: S0898-6568(20)30138-8
doi: 10.1016/j.cellsig.2020.109661
pii:
doi:

Substances chimiques

BAMBI protein, human 0
Fibrin Fibrinogen Degradation Products 0
Integrin alphaVbeta3 0
Membrane Proteins 0
Toll-Like Receptor 4 0
Transforming Growth Factor beta 0
fibrin fragment E-2 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

109661

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that there is no conflict of interest.

Auteurs

Peder Öhman Fuchs (PÖ)

Dept. of Medical Cell Biology, Uppsala University, P.O. Box 571, SE-751 23 Uppsala, Sweden.

Carlemi Calitz (C)

Dept. of Medical Cell Biology, Uppsala University, P.O. Box 571, SE-751 23 Uppsala, Sweden.

Nataša Pavlović (N)

Dept. of Medical Cell Biology, Uppsala University, P.O. Box 571, SE-751 23 Uppsala, Sweden.

François Binet (F)

Dept. of Medical Cell Biology, Uppsala University, P.O. Box 571, SE-751 23 Uppsala, Sweden.

Sara Marie Øie Solbak (SMØ)

Dept. of Chemistry-BMC, Uppsala University, P.O. Box 576, SE-751 23 Uppsala, Sweden.

U Helena Danielson (UH)

Dept. of Chemistry-BMC, Uppsala University, P.O. Box 576, SE-751 23 Uppsala, Sweden; Science for Life Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden.

Johan Kreuger (J)

Dept. of Medical Cell Biology, Uppsala University, P.O. Box 571, SE-751 23 Uppsala, Sweden.

Femke Heindryckx (F)

Dept. of Medical Cell Biology, Uppsala University, P.O. Box 571, SE-751 23 Uppsala, Sweden. Electronic address: femke.heindryckx@mcb.uu.se.

Pär Gerwins (P)

Dept. of Medical Cell Biology, Uppsala University, P.O. Box 571, SE-751 23 Uppsala, Sweden; Dept. of Radiology, Uppsala University Hospital, SE-751 85 Uppsala, Sweden.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Locomotion › Taxie › Chimiotaxie › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Précurseurs de protéines › Produits de dégradation de la fibrine et du fibrinogène › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Glycoprotéines de membrane plaquettaire › Intégrine alphaVbêta3 › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › Myofibroblastes › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu sous-cutané › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-4 › Fibrin fragment E potentiates TGF-β-induced...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de la superfamille du TGF bêta › Facteur de croissance transformant bêta › Fibrin fragment E potentiates TGF-β-induced...