Epithelial-Mesenchymal Transition in Cancer: A Historical Overview.
Journal
Translational oncology
ISSN: 1936-5233
Titre abrégé: Transl Oncol
Pays: United States
ID NLM: 101472619
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
28
02
2020
revised:
26
03
2020
accepted:
01
04
2020
pubmed:
26
4
2020
medline:
26
4
2020
entrez:
26
4
2020
Statut:
ppublish
Résumé
Epithelial-mesenchymal transitions (EMTs), the acquisition of mesenchymal features from epithelial cells, occur during some biological processes and are classified into three types: the first type occurs during embryonic development, the second type is associated with adult tissue regeneration, and the third type occurs in cancer progression. EMT occurring during embryonic development in gastrulation, renal development, and the origin and fate of the neural crest is a highly regulated process, while EMT occurring during tumor progression is highly deregulated. EMT allows the solid tumors to become more malignant, increasing their invasiveness and metastatic activity. Secondary tumors frequently maintain the typical histologic characteristics of the primary tumor. These histologic features connecting the secondary metastatic tumors to the primary is due to a process called mesenchymal-epithelial transition (MET). MET has been demonstrated in different mesenchymal tumors and is the expression of the reversibility of EMT. EMT modulation could constitute an approach to avoid metastasis. Some of the targeted small molecules utilized as antiproliferative agents have revealed to inhibit EMT initiation or maintenance because EMT is regulated through signaling pathways for which these molecules have been designed.
Identifiants
pubmed: 32334405
pii: S1936-5233(20)30250-3
doi: 10.1016/j.tranon.2020.100773
pmc: PMC7182759
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100773Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
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