Brain morphologic abnormalities in migraine patients: an observational study.
Aura
Magnetic resonance imaging
Migraine
No Aura
Voxel-based Morphometry
Journal
The journal of headache and pain
ISSN: 1129-2377
Titre abrégé: J Headache Pain
Pays: England
ID NLM: 100940562
Informations de publication
Date de publication:
25 Apr 2020
25 Apr 2020
Historique:
received:
12
02
2020
accepted:
13
04
2020
entrez:
27
4
2020
pubmed:
27
4
2020
medline:
1
9
2020
Statut:
epublish
Résumé
Migraine is a common neurological disorder characterized by a complex physiopathology. We assessed brain morphologic differences in migraine and the possible pathogenetic mechanism underlying this disease. We analyzed brain morphologic images of migraine patients, 14 with aura (MwA) [the mean (SD) age was 42.36 (2.95) years (range, 37-47)] and 14 without aura (MwoA) [the mean (SD) age was 43.5 (3.25) years (range, 39-50)] during episodic attack compared with health subjects balanced (HS) [the mean (SD) age was 42.5 (5.17) years (range, 34-51)]. All subjects underwent a Magnetic Resonance Imaging (MRI) examination with a scanner operating at 3.0 T and voxel based morphometry (VBM) approach was used to examine the gray matter volume (GMV). The statistical analysis to compare clinicl characteristics was performed using unpaired t-test an one-way Anova. Total cerebral GMV showed a significant difference between MwA and HS (p = 0.02), and between MwoA and HS (p = 0.003). In addition, not significative differences were found between MwA and MwoA groups (p = 0.17). We found three clusters of regions which showed significant GMV reduction in MwA compared with MwoA. MwA subjects showed a less of GMV in 4 clusters if compared with HS, and MwoA subjects showed a less of GMV in 3 clusters if compared with HS. We observed that MwA and MwoA patients had a significant reduction of GMV in the frontal and temporal lobe and the cerebellum, if compared to HS. The bilateral fusiform gyrus and the cingulate gyrus were increase in MwoA patients compared with HS. Our findings could provide a approach to understand possible differences in the pathogenesis of two type of migraine.
Sections du résumé
BACKGROUND
BACKGROUND
Migraine is a common neurological disorder characterized by a complex physiopathology. We assessed brain morphologic differences in migraine and the possible pathogenetic mechanism underlying this disease.
METHODS
METHODS
We analyzed brain morphologic images of migraine patients, 14 with aura (MwA) [the mean (SD) age was 42.36 (2.95) years (range, 37-47)] and 14 without aura (MwoA) [the mean (SD) age was 43.5 (3.25) years (range, 39-50)] during episodic attack compared with health subjects balanced (HS) [the mean (SD) age was 42.5 (5.17) years (range, 34-51)]. All subjects underwent a Magnetic Resonance Imaging (MRI) examination with a scanner operating at 3.0 T and voxel based morphometry (VBM) approach was used to examine the gray matter volume (GMV). The statistical analysis to compare clinicl characteristics was performed using unpaired t-test an one-way Anova.
RESULTS
RESULTS
Total cerebral GMV showed a significant difference between MwA and HS (p = 0.02), and between MwoA and HS (p = 0.003). In addition, not significative differences were found between MwA and MwoA groups (p = 0.17). We found three clusters of regions which showed significant GMV reduction in MwA compared with MwoA. MwA subjects showed a less of GMV in 4 clusters if compared with HS, and MwoA subjects showed a less of GMV in 3 clusters if compared with HS. We observed that MwA and MwoA patients had a significant reduction of GMV in the frontal and temporal lobe and the cerebellum, if compared to HS. The bilateral fusiform gyrus and the cingulate gyrus were increase in MwoA patients compared with HS.
CONCLUSION
CONCLUSIONS
Our findings could provide a approach to understand possible differences in the pathogenesis of two type of migraine.
Identifiants
pubmed: 32334532
doi: 10.1186/s10194-020-01109-2
pii: 10.1186/s10194-020-01109-2
pmc: PMC7183590
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
39Références
Imaging Med. 2013 Jun 1;5(3):
pubmed: 24319498
J Neurosci. 2009 Aug 5;29(31):9661-4
pubmed: 19657018
Trends Cogn Sci. 2008 Aug;12(8):306-13
pubmed: 18606561
Neurology. 2009 Mar 3;72(9):813-20
pubmed: 19255408
Neuroimage. 2004 May;22(1):447-55
pubmed: 15110038
Science. 2002 Mar 1;295(5560):1737-40
pubmed: 11834781
Headache. 2008 Jul;48(7):1044-55
pubmed: 18479421
Pain. 2000 Sep;87(3):295-302
pubmed: 10963909
J Cereb Blood Flow Metab. 2019 Apr;39(4):730-739
pubmed: 28737061
Cephalalgia. 2013 Jul;33(9):629-808
pubmed: 23771276
Headache. 2008 Jan;48(1):109-17
pubmed: 18184293
Neurosci Lett. 2008 Aug 1;440(2):92-6
pubmed: 18556120
Neurol Sci. 2017 Apr;38(4):553-562
pubmed: 28101762
J Headache Pain. 2017 Dec;18(1):72
pubmed: 28730563
NMR Biomed. 2013 Jan;26(1):58-64
pubmed: 22674568
Cephalalgia. 2008 Jan;28(1):1-4
pubmed: 17986275
Brain. 2018 Mar 1;141(3):822-836
pubmed: 29309542
Cephalalgia. 2008 Jun;28(6):598-604
pubmed: 18422725
Curr Opin Neurol. 2012 Jun;25(3):252-62
pubmed: 22487570
Neuroimage Clin. 2017 Jan 19;14:130-140
pubmed: 28180071
Int J Environ Res Public Health. 2018 Jun 21;15(7):
pubmed: 29933587
Lancet Neurol. 2009 Jun;8(6):560-8
pubmed: 19446275