A national survey on fungal infection diagnostic capacity in the clinical mycology laboratories of tertiary care hospitals in China.

China Clinical Laboratory Services / statistics & numerical data Diagnostic Tests, Routine / statistics & numerical data Humans Microbial Sensitivity Tests / statistics & numerical data Mycological Typing Techniques / statistics & numerical data Mycology / statistics & numerical data Mycoses / diagnosis Serology / statistics & numerical data Surveys and Questionnaires
China Diagnostic capacity Fungal infection Mycology laboratories

Journal

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
ISSN: 1995-9133
Titre abrégé: J Microbiol Immunol Infect
Pays: England
ID NLM: 100956211

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 14 02 2020
accepted: 13 03 2020
pubmed: 27 4 2020
medline: 7 7 2021
entrez: 27 4 2020
Statut: ppublish

Résumé

As the incidence of fungal infections in China increases, the demand for rapid and accurate diagnosis of mycoses is growing. Yet, information on current diagnostic capacity is scarce. An online survey was conducted in February 2018 to collect information on mycology testing from tertiary care hospitals across China. Responses from 348 hospitals were analyzed, and a scoring system was designed and employed to assess the overall diagnostic capacity. Most of the surveyed hospitals did not have separate laboratory space, manpower, or equipment dedicated for fungal testing. Conventional staining methods were widely available (>70%), whereas GMS and fluorescent staining were less common. Fungal identification services were offered mostly with chromogenic medium, morphological characterization or automated identification systems, other than more advanced methods such as MALDI-TOF MS and DNA sequencing. Fungal serology testing was available in 81.1%, with G test being the most often used. Though 91.8% of the respondents had the ability to perform antifungal susceptibility testing for yeasts, less than 13% conducted such testing for molds. The percentage of laboratories participating in External Quality Assessment programs and research was 57.5% and 32.5%, respectively. The average score for the 348 surveyed hospitals was 37.2 (out of a maximum of 89 points), with only 15 hospitals scoring >60, suggesting a general lack of high-quality mycology laboratories. The overall clinical testing capacity for fungal infection in China is insufficient. More investment and training efforts are warranted to establish centers of excellence and promote access to high-quality diagnostic services.

Sections du résumé

BACKGROUND/PURPOSE OBJECTIVE
As the incidence of fungal infections in China increases, the demand for rapid and accurate diagnosis of mycoses is growing. Yet, information on current diagnostic capacity is scarce.
METHODS METHODS
An online survey was conducted in February 2018 to collect information on mycology testing from tertiary care hospitals across China. Responses from 348 hospitals were analyzed, and a scoring system was designed and employed to assess the overall diagnostic capacity.
RESULTS RESULTS
Most of the surveyed hospitals did not have separate laboratory space, manpower, or equipment dedicated for fungal testing. Conventional staining methods were widely available (>70%), whereas GMS and fluorescent staining were less common. Fungal identification services were offered mostly with chromogenic medium, morphological characterization or automated identification systems, other than more advanced methods such as MALDI-TOF MS and DNA sequencing. Fungal serology testing was available in 81.1%, with G test being the most often used. Though 91.8% of the respondents had the ability to perform antifungal susceptibility testing for yeasts, less than 13% conducted such testing for molds. The percentage of laboratories participating in External Quality Assessment programs and research was 57.5% and 32.5%, respectively. The average score for the 348 surveyed hospitals was 37.2 (out of a maximum of 89 points), with only 15 hospitals scoring >60, suggesting a general lack of high-quality mycology laboratories.
CONCLUSIONS CONCLUSIONS
The overall clinical testing capacity for fungal infection in China is insufficient. More investment and training efforts are warranted to establish centers of excellence and promote access to high-quality diagnostic services.

Identifiants

DOI: 10.1016/j.jmii.2020.03.016 PMID: 32334978
pubmed: 32334978
pii: S1684-1182(20)30076-1
doi: 10.1016/j.jmii.2020.03.016
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

845-853

Informations de copyright

Copyright © 2020. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest We declare no conflicts of interest.

Auteurs

He Wang (H)

Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China; Dynamiker Sub-Center of Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Disease, Tianjin, China.

Yao Wang (Y)

Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Disease, Beijing, China.

Qi-Wen Yang (QW)

Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Disease, Beijing, China.

Yu-Xing Ni (YX)

Department of Clinical Microbiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Li-Kai Lin (LK)

Hospital Management Research Institute, Wuhan University, Wuhan, Hubei, China.

Yan-Ping Luo (YP)

Center for Clinical Laboratory Medicine, PLA General Hospital, Beijing, China.

Zi-Yong Sun (ZY)

Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Min Li (M)

Department of Laboratory Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Wen-Juan Wu (WJ)

Department of Laboratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Qiang-Qiang Zhang (QQ)

Laboratory of Mycology, Huashan Hospital, Fudan University, Shanghai, China.

Dan-Hong Su (DH)

The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Hua Yu (H)

Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.

Mei Kang (M)

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

He-Ping Xu (HP)

Department of Clinical Laboratory, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.

Wei Liu (W)

Department of Dermatology, Peking University First Hospital, Peking University, Beijing, China.

Qing Yang (Q)

Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Cui Jian (C)

Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Li-Na Guo (LN)

Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Disease, Beijing, China.

Wen-Hang Yang (WH)

Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Disease, Beijing, China.

Meng Xiao (M)

Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Disease, Beijing, China. Electronic address: cjtcxiaomeng@aliyun.com.

Po-Ren Hsueh (PR)

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: hsporen@ntu.edu.tw.

Ying-Chun Xu (YC)

Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Disease, Beijing, China. Electronic address: xycpumch@139.com.

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Classifications MeSH

questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › A national survey on fungal infection...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Services de médecine préventive › Services de diagnostic › Services de laboratoire d'analyses médicales › A national survey on fungal infection...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Tests diagnostiques courants › A national survey on fungal infection...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A national survey on fungal infection...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › A national survey on fungal infection...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Techniques microbiologiques › Techniques de typage mycologique › A national survey on fungal infection...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Microbiologie › Mycologie › A national survey on fungal infection...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Mycoses › A national survey on fungal infection...
questionsmedicales.fr › Professions de santé › Sérologie › A national survey on fungal infection...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › A national survey on fungal infection...