Photodynamic inactivation of methicillin-resistant Staphylococcus aureus on skin using a porphyrinic formulation.
Antimicrobial photodynamic therapy
Iodopovidone
Methicillin-resistant Staphylococcus aureus
Porphyrinic formulation
Potassium iodide
Potentiator agents
Journal
Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
04
01
2020
revised:
16
03
2020
accepted:
30
03
2020
pubmed:
27
4
2020
medline:
15
5
2021
entrez:
27
4
2020
Statut:
ppublish
Résumé
Staphylococcus aureus is responsible for skin and soft tissue infections. Having in mind increased antibiotic resistance, in this study the efficacy of antimicrobial photodynamic therapy (aPDT) with a porphyrinic formulation (FORM) as photosensitizer (PS) to photoinactivate methicillin-resistant Staphylococcus aureus (MRSA) on skin was evaluated. Potassium iodide (KI) and iodopovidone (PVP-I) were also tested in combination with FORM as potentiator agents of FORM efficacy. The aPDT protocol was first developed in Phosphate Buffered Saline (PBS, in vitro). Porcine skin was artificially contaminated with MRSA (ex vivo) and treated with FORM, FORM + KI or FORM + PVP-I under white light. The in vitro results showed that FORM was effective to inactivate MRSA. A substantial reduction in the irradiation time, when compared to FORM alone, was observed for FORM + KI and FORM + PVP-I combinations. On skin, reductions in MRSA survival of 3.1 Log
Identifiants
pubmed: 32335190
pii: S1572-1000(20)30107-1
doi: 10.1016/j.pdpdt.2020.101754
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Photosensitizing Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101754Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.