High-resolution views of lipopolysaccharide translocation driven by ABC transporters MsbA and LptB

ATP-Binding Cassette Transporters / antagonists & inhibitors Bacterial Proteins / antagonists & inhibitors Carrier Proteins Lipopolysaccharides / chemistry Models, Molecular Molecular Structure Protein Binding Protein Conformation Protein Transport Signal Transduction Structure-Activity Relationship

Journal

Current opinion in structural biology
ISSN: 1879-033X
Titre abrégé: Curr Opin Struct Biol
Pays: England
ID NLM: 9107784

Informations de publication

Date de publication:
08 2020
Historique:
received: 01 12 2019
revised: 18 02 2020
accepted: 06 03 2020
pubmed: 27 4 2020
medline: 22 7 2021
entrez: 27 4 2020
Statut: ppublish

Résumé

Gram-negative bacteria possess a dual-membrane envelope, which provides defense against environmental assault, as well as formidable resistance against antibiotics. Lipopolysaccharide (LPS) is the primary lipid component in the outermost membrane leaflet of most Gram-negative bacteria, and plays critical roles in cell envelope formation. Newly synthesized LPS at the cytoplasmic side of the inner membrane is flipped across the inner membrane and pushed across the periplasm by two ATP-binding cassette transporters, MsbA and LptB

Identifiants

DOI: 10.1016/j.sbi.2020.03.005 PMID: 32335504 PMC: PMC7442718
pubmed: 32335504
pii: S0959-440X(20)30045-2
doi: 10.1016/j.sbi.2020.03.005
pmc: PMC7442718
mid: NIHMS1578415
pii:
doi:

Substances chimiques

ATP-Binding Cassette Transporters 0
Bacterial Proteins 0
Carrier Proteins 0
Lipopolysaccharides 0
MsbA protein, Bacteria 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

26-33

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM122797
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Références

J Biol Chem. 2019 Mar 29;294(13):5181-5197
pubmed: 30804214
Int J Antimicrob Agents. 2019 Apr;53(4):442-448
pubmed: 30476569
Structure. 2017 Aug 1;25(8):1264-1274.e3
pubmed: 28712805
Trends Biochem Sci. 2019 Oct;44(10):837-848
pubmed: 31078399
Nat Rev Mol Cell Biol. 2009 Mar;10(3):218-27
pubmed: 19234479
Essays Biochem. 2011 Sep 7;50(1):1-17
pubmed: 21967049
Science. 2018 Feb 16;359(6377):798-801
pubmed: 29449493
Nat Struct Mol Biol. 2017 May;24(5):469-474
pubmed: 28394325
Annu Rev Biochem. 2014;83:99-128
pubmed: 24580642
Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6834-6839
pubmed: 29735709
Nature. 2019 Mar;567(7749):486-490
pubmed: 30894744
Science. 2010 Feb 19;327(5968):1010-3
pubmed: 20167788
Nat Immunol. 2019 May;20(5):527-533
pubmed: 30962589
Sci Adv. 2018 Nov 14;4(11):eaau2634
pubmed: 30443594
Nat Rev Microbiol. 2016 Jun;14(6):337-45
pubmed: 27026255
Nat Rev Microbiol. 2009 Sep;7(9):677-83
pubmed: 19633680
Cell. 2015 Apr 23;161(3):438-449
pubmed: 25910204
J Mol Biol. 2008 Jul 11;380(3):476-88
pubmed: 18534617
Nature. 2019 Mar;567(7749):550-553
pubmed: 30894747
Nature. 2018 May;557(7704):196-201
pubmed: 29720648
Nature. 2009 Apr 30;458(7242):1191-5
pubmed: 19252480
Nat Rev Microbiol. 2019 Jul;17(7):403-416
pubmed: 31142822
Nature. 2017 Sep 14;549(7671):233-237
pubmed: 28869968
Mol Microbiol. 2018 Aug;109(4):541-554
pubmed: 29995974
Antimicrob Agents Chemother. 2018 Oct 24;62(11):
pubmed: 30104274
Nat Commun. 2017 Aug 9;8(1):222
pubmed: 28790314
J Bacteriol. 2013 Mar;195(5):1100-8
pubmed: 23292770
Science. 2019 Sep 13;365(6458):1149-1155
pubmed: 31416931
J Am Chem Soc. 2017 Dec 6;139(48):17221-17224
pubmed: 29135241
Science. 2005 May 13;308(5724):1023-8
pubmed: 15890883
Nature. 2014 Jul 3;511(7507):52-6
pubmed: 24990744
J Mol Biol. 2009 Oct 30;393(3):574-85
pubmed: 19715704
PLoS One. 2016 Aug 16;11(8):e0161354
pubmed: 27529623
Science. 2013 May 17;340(6134):837-41
pubmed: 23687042
Chem Rev. 2017 Mar 22;117(6):4669-4713
pubmed: 28177242
Clin Infect Dis. 2009 Jan 1;48(1):1-12
pubmed: 19035777
Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):19005-10
pubmed: 18024585
J Mol Biol. 2009 Oct 30;393(3):586-97
pubmed: 19715702
J Biol Chem. 2010 Oct 22;285(43):33529-39
pubmed: 20720015
Nat Struct Mol Biol. 2016 Jun 7;23(6):487-93
pubmed: 27273632
Curr Opin Struct Biol. 2018 Aug;51:116-128
pubmed: 29635113
Nat Struct Mol Biol. 2019 Sep;26(9):792-801
pubmed: 31451804
Chembiochem. 2012 Aug 13;13(12):1767-75
pubmed: 22807320
Structure. 2016 Jun 7;24(6):965-976
pubmed: 27161977
Annu Rev Biochem. 2007;76:295-329
pubmed: 17362200
Bioorg Med Chem. 2016 Dec 15;24(24):6332-6339
pubmed: 27240465
PLoS Biol. 2007 Oct;5(10):e271
pubmed: 17927448

Auteurs

François Thélot (F)

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA; Biological and Biomedical Sciences Program, Harvard University, Cambridge, MA 02138, USA.

Benjamin J Orlando (BJ)

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

Yanyan Li (Y)

Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, China. Electronic address: liyanyan@westlake.edu.cn.

Maofu Liao (M)

Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: maofu_liao@hms.harvard.edu.

Articles similaires

Atomic view of photosynthetic metabolite permeability pathways and confinement in synthetic carboxysome shells.

Daipayan Sarkar, Christopher Maffeo, Markus Sutter et al.
1.00
Photosynthesis Ribulose-Bisphosphate Carboxylase Carbon Dioxide Molecular Dynamics Simulation Cyanobacteria

Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases.

Arpine Sokratian, Ye Zhou, Meltem Tatli et al.
1.00
alpha-Synuclein Humans Animals Mice Lewy Body Disease

The FGF/FGFR/c-Myc axis as a promising therapeutic target in multiple myeloma.

Arianna Giacomini, Sara Taranto, Giorgia Gazzaroli et al.
1.00
Humans Multiple Myeloma Receptors, Fibroblast Growth Factor Fibroblast Growth Factors Proto-Oncogene Proteins c-myc

Myosin-binding protein-H: Not just filler.

David Y Barefield
1.00
Animals Humans Sarcomeres Muscle Proteins Carrier Proteins

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › High-resolution views of lipopolysaccharide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › High-resolution views of lipopolysaccharide...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › High-resolution views of lipopolysaccharide...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › High-resolution views of lipopolysaccharide...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › High-resolution views of lipopolysaccharide...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › High-resolution views of lipopolysaccharide...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › High-resolution views of lipopolysaccharide...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › High-resolution views of lipopolysaccharide...
questionsmedicales.fr › Métabolisme › Transport biologique › Transport des protéines › High-resolution views of lipopolysaccharide...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › High-resolution views of lipopolysaccharide...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › High-resolution views of lipopolysaccharide...