Nicotinic Acetylcholine Receptors of PC12 Cells.
PC12
nAChRs
Α3β4
Α4β2
Α7
Α9
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
24
11
2019
accepted:
09
04
2020
pubmed:
27
4
2020
medline:
12
8
2021
entrez:
27
4
2020
Statut:
ppublish
Résumé
Nicotinic acetylcholine receptors (nAChRs) have gained much attention in the scientific community since they play a significant role in multiple physiological and pathophysiological processes. Multiple approaches to study the receptors exist, with characterization of the receptors' functionality at a single cellular level using cell culturing being one of them. Derived from an adrenal medulla tumor, PC12 cells express nicotinic receptor subunits and form functional nicotinic receptors. Thus, the cells offer a convenient environment to address questions related to the functionality of the receptors. The review summarizes the findings on nicotinic receptors' expression and functions which were conducted using PC12 cells. Specific focus is given to α3-containing receptors as well as α7 receptor. Critical evaluation of findings is provided alongside insights into what can still be learned about nAChRs, using PC12 cells.
Identifiants
pubmed: 32335772
doi: 10.1007/s10571-020-00846-x
pii: 10.1007/s10571-020-00846-x
doi:
Substances chimiques
Protein Subunits
0
Receptors, Nicotinic
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-29Subventions
Organisme : Nazarbayev University
ID : 110119FD4517
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