Monte Carlo simulation of digital photon counting PET.

Digital photon counting Monte Carlo simulation NEMA PET

Journal

EJNMMI physics
ISSN: 2197-7364
Titre abrégé: EJNMMI Phys
Pays: Germany
ID NLM: 101658952

Informations de publication

Date de publication:
25 Apr 2020
Historique:
received: 13 12 2019
accepted: 17 03 2020
entrez: 27 4 2020
pubmed: 27 4 2020
medline: 27 4 2020
Statut: epublish

Résumé

A GATE Monte Carlo model of the Philips Vereos digital photon counting PET imaging system using silicon photo-multiplier detectors was proposed. It was evaluated against experimental data in accordance with NEMA guidelines. Comparisons were performed using listmode data in order to remain independent of image reconstruction algorithms. An original line of response-based method is proposed to estimate intrinsic spatial resolution without reconstruction. Four sets of experiments were performed: (1) count rates and scatter fraction, (2) energy and timing resolutions, (3) sensitivity, and (4) intrinsic spatial resolution. Experimental and simulated data were found to be in good agreement, with overall differences lower than 10% for activity concentrations used in most standard clinical applications. Illustrative image reconstructions were provided. In conclusion, the proposed Monte Carlo model was validated and can be used for numerous studies such as optimizing acquisition parameters or reconstruction algorithms.

Identifiants

pubmed: 32335787
doi: 10.1186/s40658-020-00288-w
pii: 10.1186/s40658-020-00288-w
pmc: PMC7183520
doi:

Types de publication

Journal Article

Langues

eng

Pagination

23

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Auteurs

Julien Salvadori (J)

IADI, INSERM UMR 1254, Université de Lorraine, Nancy, France. j.salvadori89@gmail.com.
Département de médecine nucléaire et plateforme Nancyclotep, CHRU-Nancy, Université de Lorraine, Nancy, France. j.salvadori89@gmail.com.

Joey Labour (J)

CREATIS, Centre Léon Bérard, CNRS UMR 5220, INSERM U 1044, Université de Lyon; INSA-Lyon; Université Lyon 1, Lyon, France.

Freddy Odille (F)

IADI, INSERM UMR 1254, Université de Lorraine, Nancy, France.

Pierre-Yves Marie (PY)

Département de médecine nucléaire et plateforme Nancyclotep, CHRU-Nancy, Université de Lorraine, Nancy, France.
DCAC, INSERM UMR 1116, Université de Lorraine, Nancy, France.

Jean-Noël Badel (JN)

CREATIS, Centre Léon Bérard, CNRS UMR 5220, INSERM U 1044, Université de Lyon; INSA-Lyon; Université Lyon 1, Lyon, France.

Laëtitia Imbert (L)

IADI, INSERM UMR 1254, Université de Lorraine, Nancy, France.
Département de médecine nucléaire et plateforme Nancyclotep, CHRU-Nancy, Université de Lorraine, Nancy, France.

David Sarrut (D)

CREATIS, Centre Léon Bérard, CNRS UMR 5220, INSERM U 1044, Université de Lyon; INSA-Lyon; Université Lyon 1, Lyon, France.

Classifications MeSH