Unraveling ERBB network dynamics upon betacellulin signaling in pancreatic ductal adenocarcinoma in mice.
Adenocarcinoma
/ metabolism
Animals
Betacellulin
/ metabolism
Body Weight
Carcinoma, Pancreatic Ductal
/ metabolism
ErbB Receptors
/ metabolism
Humans
Mice, Transgenic
Pancreas
/ metabolism
Pancreatic Neoplasms
/ metabolism
Phenotype
Phosphorylation
Receptor, ErbB-2
/ metabolism
Receptor, ErbB-4
/ metabolism
Signal Transduction
Tumor Burden
ras Proteins
/ metabolism
Pancreatic Neoplasms
BTC
EGFR
ERBB2
ERBB4
PDAC
mouse model
Journal
Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
28
10
2019
revised:
17
02
2020
accepted:
06
04
2020
pubmed:
27
4
2020
medline:
1
7
2021
entrez:
27
4
2020
Statut:
ppublish
Résumé
Pancreatic ductal adenocarcinoma (PDAC) will soon belong to the top three cancer killers. The only approved specific PDAC therapy targets the epidermal growth factor receptor (EGFR). Although EGFR is a crucial player in PDAC development, EGFR-based therapy is disappointing. In this study, we evaluated the role of the EGFR ligand betacellulin (BTC) in PDAC. The expression of BTC was investigated in human pancreatic cancer specimen. Then, we generated a BTC knockout mouse model by CRISPR/Cas9 technology and a BTC overexpression model. Both models were crossed with the Ptf1a
Identifiants
pubmed: 32335999
doi: 10.1002/1878-0261.12699
pmc: PMC7400790
doi:
Substances chimiques
Betacellulin
0
ErbB Receptors
EC 2.7.10.1
Receptor, ErbB-2
EC 2.7.10.1
Receptor, ErbB-4
EC 2.7.10.1
ras Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1653-1669Subventions
Organisme : Fritz Thyssen Stiftung
ID : 10.18.1.030MN
Pays : International
Informations de copyright
© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.
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