Treatment of SARS-CoV-2: How far have we reached?

Adenosine Monophosphate / analogs & derivatives Alanine / analogs & derivatives Amides / therapeutic use Antibodies, Monoclonal, Humanized / therapeutic use Antiviral Agents / therapeutic use Betacoronavirus COVID-19 Chloroquine / therapeutic use Clinical Trials as Topic Coronavirus Infections / drug therapy Darunavir / therapeutic use Drug Combinations Humans Hydroxychloroquine / therapeutic use Immunization, Passive Indoles / therapeutic use Interferon-alpha / therapeutic use Interferon-beta / therapeutic use Lopinavir / therapeutic use Pandemics Pneumonia, Viral / therapy Pyrazines / therapeutic use Ritonavir / therapeutic use SARS-CoV-2 COVID-19 Drug Treatment COVID-19 Serotherapy
SARS-CoV-2 antiviral clinical trial corona virus pandemic

Journal

Drug discoveries & therapeutics
ISSN: 1881-784X
Titre abrégé: Drug Discov Ther
Pays: Japan
ID NLM: 101493809

Informations de publication

Date de publication:
06 May 2020
Historique:
pubmed: 28 4 2020
medline: 10 5 2020
entrez: 28 4 2020
Statut: ppublish

Résumé

The virus severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is currently affecting more than 200 countries and territories worldwide. It has been declared as pandemic by World Health Organization (WHO) and the whole world is suffering from corona virus disease 2019 (COVID-19). Currently, no treatment for SARS-CoV-2 are approved because of lack of evidence, but a number of clinical trials are in process and we are expecting fruitful results very soon. This review focuses on various approaches of treatment and few of the most recent clinical trials carried out in this field.

Identifiants

DOI: 10.5582/ddt.2020.03008 PMID: 32336723
pubmed: 32336723
doi: 10.5582/ddt.2020.03008
doi:

Substances chimiques

Amides 0
Antibodies, Monoclonal, Humanized 0
Antiviral Agents 0
Drug Combinations 0
Indoles 0
Interferon-alpha 0
Pyrazines 0
lopinavir-ritonavir drug combination 0
Lopinavir 2494G1JF75
remdesivir 3QKI37EEHE
Adenosine Monophosphate 415SHH325A
Hydroxychloroquine 4QWG6N8QKH
Interferon-beta 77238-31-4
Chloroquine 886U3H6UFF
umifenovir 93M09WW4RU
favipiravir EW5GL2X7E0
sarilumab NU90V55F8I
Ritonavir O3J8G9O825
Alanine OF5P57N2ZX
Darunavir YO603Y8113

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

67-72

Auteurs

Waquar Ahsan (W)

Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

Shamama Javed (S)

Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

Mohammed Al Bratty (MA)

Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

Hassan A Alhazmi (HA)

Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, Saudi Arabia.

Asim Najmi (A)

Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › AMP › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Alanine › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Composés chimiques organiques › Amides › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Aminoquinoléines › Chloroquine › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Nidovirales › Infections à Coronaviridae › Infections à coronavirus › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Furanes › Darunavir › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Préparations pharmaceutiques › Association médicamenteuse › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Aminoquinoléines › Chloroquine › Hydroxychloroquine › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Interféron alpha › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interférons › Interféron de type I › Interféron bêta › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Pyrimidinones › Lopinavir › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Environnement et santé publique › Santé publique › Épidémies de maladies › Épidémies › Pandémies › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrazines › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Thiazoles › Ritonavir › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitements médicamenteux de la COVID-19 › Treatment of SARS-CoV-2: How far have we reached?
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Sérothérapie COVID-19 › Treatment of SARS-CoV-2: How far have we reached?