Circulating tumor cells and breast cancer-specific mutations in primary breast cancer.

BRCA1/2 circulating tumor cells epithelial-to-mesenchymal transition primary breast cancer targeted resequencing

Journal

Molecular and clinical oncology
ISSN: 2049-9450
Titre abrégé: Mol Clin Oncol
Pays: England
ID NLM: 101613422

Informations de publication

Date de publication:
Jun 2020
Historique:
received: 20 02 2019
accepted: 29 01 2020
entrez: 28 4 2020
pubmed: 28 4 2020
medline: 28 4 2020
Statut: ppublish

Résumé

Circulating tumor cells (CTCs) play a pivotal role in tumor dissemination and progression, and are considered to be a critical part of the metastatic cascade. The aim of the present research article was to examine breast cancer-specific mutations in primary breast cancer (PBC) using targeted resequencing. A total of 78 patients with PBC were enrolled into this translational study. Reverse transcription-quantitative PCR assay for the expression of epithelial markers (

Identifiants

pubmed: 32337039
doi: 10.3892/mco.2020.2026
pii: MCO-0-0-2026
pmc: PMC7179389
doi:

Types de publication

Journal Article

Langues

eng

Pagination

565-573

Informations de copyright

Copyright © 2020, Spandidos Publications.

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Auteurs

Michal Mego (M)

Second Department of Medical Oncology, Faculty of Medicine, Comenius University, 833 10 Bratislava, Slovakia.
National Cancer Institute, 833 10 Bratislava, Slovakia.

Marian Karaba (M)

National Cancer Institute, 833 10 Bratislava, Slovakia.

Tatiana Sedlackova (T)

Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia.

Juraj Benca (J)

National Cancer Institute, 833 10 Bratislava, Slovakia.
Department of Medicine, St. Elizabeth University, 811 02 Bratislava, Slovakia.

Gabriela Repiska (G)

Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia.

Lucia Krasnicanova (L)

Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia.

Jan Macuch (J)

National Cancer Institute, 833 10 Bratislava, Slovakia.

Gabriela Sieberova (G)

National Cancer Institute, 833 10 Bratislava, Slovakia.

Silvia Jurisova (S)

Second Department of Medical Oncology, Faculty of Medicine, Comenius University, 833 10 Bratislava, Slovakia.
National Cancer Institute, 833 10 Bratislava, Slovakia.

Daniel Pindak (D)

National Cancer Institute, 833 10 Bratislava, Slovakia.
Slovak Medical University, 833 03 Bratislava, Slovakia.

Katarina Kalavska (K)

Second Department of Medical Oncology, Faculty of Medicine, Comenius University, 833 10 Bratislava, Slovakia.
National Cancer Institute, 833 10 Bratislava, Slovakia.

Jozef Mardiak (J)

Second Department of Medical Oncology, Faculty of Medicine, Comenius University, 833 10 Bratislava, Slovakia.
National Cancer Institute, 833 10 Bratislava, Slovakia.

Gabriel Minarik (G)

Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, Mlynska dolina, 842 15 Bratislava, Slovakia.

Classifications MeSH