Comparative quantitative survey of patient experience in Barrett's oesophagus and other gastrointestinal disorders.
barrett’s oesophagus
endoscopy
quality of life
surveillance
Journal
BMJ open gastroenterology
ISSN: 2054-4774
Titre abrégé: BMJ Open Gastroenterol
Pays: England
ID NLM: 101660690
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
11
2019
revised:
13
01
2020
accepted:
30
01
2020
entrez:
28
4
2020
pubmed:
28
4
2020
medline:
25
11
2021
Statut:
epublish
Résumé
To assess health-related quality of life in patients with non-dysplastic Barrett's oesophagus (NDBO) and endoscopically treated dysplastic Barrett's oesophagus (DBO). This quantitative, self-administered questionnaire study was conducted across three National Health Service hospitals. Data were collected from three other cohorts; gastro-oesophageal reflux disease (GORD), colonic polyp surveillance and healthy individuals. Fisher's exact and Spearman's rank correlation tests were used for analysis. Propensity score matching adjusted for age, sex and comorbidities. 687 participants were eligible for analysis (NDBO n=306, DBO n=49, GORD n=132, colonic polyps n=152 and healthy n=48). 53% of NDBO participants reported similarly high cancer worry, comparable to DBO (50%, p=0.933) and colonic polyp participants (51%, p=0.355). Less cancer worry was reported in GORD participants (43.4%, p=0.01 vs NDBO). NDBO participants reported anxiety in 15.8% and depression in 8.6% of cases, which was similar to the other disease cohorts. Moderate or severe heartburn or acid regurgitation was found in 11% and 10%, respectively, in the NDBO cohort, comparable to DBO participants (heartburn 2% p=0.172, acid regurgitation 4% p=0.31) but lower (better) than GORD participants (heartburn 31% p=<0.001, acid regurgitation 25% p=0.001). NDBO participants with moderate or severe GORD symptoms were associated with higher rates of anxiety (p=<0.001), depression (p=<0.001) and cancer worry (p=<0.001). NDBO patients appropriately perceiving their cancer risk as low had lower rates of cancer worry (p=<0.001). This study provides insight into the problems Barrett's oesophagus patients may face. Future care pathways must be more patient focussed to address misconceptions of cancer risk, oesophageal cancer related worry and GORD symptom control.
Identifiants
pubmed: 32337055
doi: 10.1136/bmjgast-2019-000357
pii: bmjgast-2019-000357
pmc: PMC7170407
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e000357Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Gut. 2012 Jul;61(7):970-6
pubmed: 21997553
Psychooncology. 2010 Mar;19(3):289-98
pubmed: 19382100
J Gastrointest Surg. 2006 Mar;10(3):341-6
pubmed: 16504878
Gastrointest Endosc. 2016 Jun;83(6):1090-1106.e3
pubmed: 26902843
Health Expect. 2019 Feb;22(1):21-33
pubmed: 30430714
J Psychosom Res. 2002 Feb;52(2):69-77
pubmed: 11832252
Support Care Cancer. 2016 Feb;24(2):555-562
pubmed: 26108170
Dis Esophagus. 2010 Aug;23(6):458-64
pubmed: 20113322
Dig Dis Sci. 1988 Feb;33(2):129-34
pubmed: 3123181
Cancer Nurs. 2014 Jan-Feb;37(1):E44-50
pubmed: 23448956
Am J Gastroenterol. 2008 Nov;103(11):2694-9
pubmed: 18853967
Eur J Gastroenterol Hepatol. 2009 Aug;21(8):850-4
pubmed: 19598328
Gastroenterology. 2005 Aug;129(2):429-36
pubmed: 16083700
Br Med J (Clin Res Ed). 1986 Feb 1;292(6516):344
pubmed: 3080166
Aliment Pharmacol Ther. 2003 May 15;17(10):1319-24
pubmed: 12755845
Psychol Med. 1997 Mar;27(2):363-70
pubmed: 9089829
Gastroenterology. 2011 Aug;141(2):460-8
pubmed: 21679712
Gastrointest Endosc. 2007 Jan;65(1):26-30
pubmed: 17185076
BMJ Qual Saf. 2016 Aug;25(8):626-32
pubmed: 26993640
Psychooncology. 2018 Nov;27(11):2609-2615
pubmed: 29843189
J Clin Oncol. 1994 Apr;12(4):843-50
pubmed: 8151327
Qual Life Res. 1998 Jan;7(1):75-83
pubmed: 9481153
Am J Gastroenterol. 2013 Feb;108(2):187-95; quiz 196
pubmed: 23247578
JAMA. 2015 Dec 8;314(22):2373-83
pubmed: 26647259
Dig Dis Sci. 2014 Jul;59(7):1378-85
pubmed: 24500449
Gut. 2010 May;59(5):666-89
pubmed: 20427401
Am J Gastroenterol. 2003 Jul;98(7):1627-33
pubmed: 12873590
BMJ Open. 2018 Jul 23;8(7):e020655
pubmed: 30037867
Lancet Oncol. 2017 Jun;18(6):823-834
pubmed: 28457708
Gut. 2008 Oct;57(10):1354-9
pubmed: 18424568
Am J Gastroenterol. 2016 Jan;111(1):30-50; quiz 51
pubmed: 26526079
Gut. 2015 Aug;64(8):1192-9
pubmed: 25539672
J Med Genet. 2001 Feb;38(2):139
pubmed: 11288719
N Engl J Med. 1999 Mar 18;340(11):825-31
pubmed: 10080844
Am J Gastroenterol. 2009 Nov;104(11):2695-703
pubmed: 19755967
Am J Gastroenterol. 2015 May;110(5):662-82; quiz 683
pubmed: 25869390
Med Care. 1992 Jun;30(6):473-83
pubmed: 1593914
Stat Sci. 2010 Feb 1;25(1):1-21
pubmed: 20871802
Gut. 2014 Jan;63(1):7-42
pubmed: 24165758
Multivariate Behav Res. 2011 May;46(3):399-424
pubmed: 21818162
Gut. 2000 Sep;47(3):444-54
pubmed: 10940286
Ann Oncol. 2012 Dec;23(12):3155-62
pubmed: 22847812
Am J Gastroenterol. 2011 Feb;106(2):254-60
pubmed: 21139576
Prev Med. 2004 Apr;38(4):388-402
pubmed: 15020172
Dis Esophagus. 2017 Feb 1;30(3):1-9
pubmed: 27766707
Endoscopy. 2010 Oct;42(10):790-9
pubmed: 20886398
J Psychosom Res. 1997 Jan;42(1):17-41
pubmed: 9055211
Lancet Gastroenterol Hepatol. 2018 Jan;3(1):57-65
pubmed: 28970029