A Sensitive Fibre Optic Probe for Autofluorescence Spectroscopy of Oral Tongue Cancer: Monte Carlo Simulation Study.
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
01
2020
revised:
11
03
2020
accepted:
25
03
2020
entrez:
28
4
2020
pubmed:
28
4
2020
medline:
30
1
2021
Statut:
epublish
Résumé
The objective of this paper is to determine the best optical probe configuration that would help to detect neoplastic lesions in oral tongue epithelial tissue. Three geometrical configurations are investigated. The first one is a single-fibre probe with different fibre diameters. The second one is a multitilted fibre probe that employs different tilting angles for emission and collection fibres. While the third one is a multidiameter probe that employs different fibre diameters and distances between the emission and the collection fibres. All probes were evaluated for their depth-limited sensitivity in the epithelium layer of the tongue. Probes that showed efficient sensitivities were then compared for their fluorescence intensities acquired from both tissue types. The sensitivity for the first two types of probes was found to be roughly comparable. However, the differentiation capability of the multitilted fibre probe between dysplastic and healthy tissue was found to be noticeably larger by 30% of that of the single-fibre probe. The third type showed more sensitivity to fluorescence emerging from deeper layers. Finally, the proposed configuration is presented and proved to achieve higher sensitivity for both superficial and deep layers.
Identifiants
pubmed: 32337228
doi: 10.1155/2020/1936570
pmc: PMC7168752
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1936570Informations de copyright
Copyright © 2020 Haneen Shhadeh et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this paper.
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