Novel Indices of Glucose Homeostasis Derived from Principal Component Analysis: Application for Metabolic Assessment in Pregnancy.
Journal
Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
05
2019
accepted:
12
03
2020
entrez:
28
4
2020
pubmed:
28
4
2020
medline:
17
2
2021
Statut:
epublish
Résumé
This study is aimed at assessing the association of previously developed indices of glucose homeostasis derived from principal component analysis (PCA) with parameters of insulin action, secretion, and beta cell function during pregnancy. In this prospective longitudinal study, an oral glucose tolerance test was performed in sixty-seven pregnant women at two prepartum (12+0 to 22+6 and 24+0 to 28+6) and one postpartum (2 to 11 months) visits. Three principal component scores (PCS) were calculated based on measurements of glucose, insulin, C-peptide, age, and BMI to assess their association with fasting and dynamic indices of insulin action, secretion, and PCS1 was positively associated with fasting and dynamic parameters of insulin sensitivity (Matsuda index: PCS1 to 3 behaved similarly as compared to previous observations in nonpregnant women and were furthermore associated with the development of GDM. These findings support our hypothesis that PCS1 to 3 could be used as novel indices of glucose disposal during pregnancy.
Identifiants
pubmed: 32337294
doi: 10.1155/2020/4950584
pmc: PMC7150715
doi:
Substances chimiques
Blood Glucose
0
C-Peptide
0
Insulin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4950584Informations de copyright
Copyright © 2020 Tina Stopp et al.
Déclaration de conflit d'intérêts
The authors have nothing to disclose.
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