Method for enhancing bioavailability of myricetin based on self-assembly of casein-myricetin nanomicelles.
Journal
IET nanobiotechnology
ISSN: 1751-875X
Titre abrégé: IET Nanobiotechnol
Pays: United States
ID NLM: 101303205
Informations de publication
Date de publication:
May 2020
May 2020
Historique:
entrez:
28
4
2020
pubmed:
28
4
2020
medline:
9
1
2021
Statut:
ppublish
Résumé
In order to expand the application in the medical field and enhance pharmacological effects, casein-myricetin nanomicelles were prepared by the self-assembly method and characterised by ultraviolet-visible spectroscopy and Fourier transform infrared spectroscopy. The parameters in self-assembly were optimised according to the factors of particle size, encapsulation yield, and drug loading. The result showed a pH of 5.5, a casein concentration of 2 mg/ml, a mass ratio of casein to myricetin of 8:1, ultrasonic power of 300 W, ultrasonic time of 5 min and ethanol volume of 7 ml were the optimal conditions. The situ cycle intestinal perfusion methods indicated that casein-myricetin nanomicelles can be more easily absorbed by small intestine than myricetin standard sample. Therefore, casein micelles are effective for improving the water solubility of myricetin.
Identifiants
pubmed: 32338633
doi: 10.1049/iet-nbt.2018.5431
pmc: PMC8676504
doi:
Substances chimiques
Caseins
0
Drug Carriers
0
Flavonoids
0
Micelles
0
myricetin
76XC01FTOJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
239-244Références
Carbohydr Polym. 2014 Sep 22;110:329-37
pubmed: 24906763
J Nanobiotechnology. 2007 Apr 17;5:3
pubmed: 17439648
J Agric Food Chem. 2016 Aug 17;64(32):6286-94
pubmed: 27455843
J Agric Food Chem. 2019 Jun 12;67(23):6614-6624
pubmed: 31117487
Crit Rev Food Sci Nutr. 2012;52(1):85-101
pubmed: 21991992
J Photochem Photobiol B. 2013 Oct 5;127:100-7
pubmed: 23973780
Eur J Pharm Sci. 2013 Mar 12;48(4-5):781-9
pubmed: 23298578
J Cell Physiol. 2019 Feb 11;:
pubmed: 30746687
J Agric Food Chem. 2019 Jun 5;67(22):6292-6301
pubmed: 31117486
J Agric Food Chem. 2014 May 21;62(20):4677-84
pubmed: 24670204
Food Chem Toxicol. 2008 Jun;46(6):2042-53
pubmed: 18331776
Cancer Lett. 2009 Oct 8;283(2):230-8
pubmed: 19398149
Mol Nutr Food Res. 2011 Feb;55(2):310-7
pubmed: 20718051
Science. 1991 Nov 29;254(5036):1312-9
pubmed: 1962191
Mol Nutr Food Res. 2011 May;55 Suppl 1:S86-92
pubmed: 21225618
AAPS PharmSci. 2001;3(3):E25
pubmed: 11741276
J Neurosci Res. 2008 Jun;86(8):1836-45
pubmed: 18265412
Phys Chem Chem Phys. 2015 Feb 7;17(5):3599-606
pubmed: 25553611
J Microencapsul. 2011;28(4):258-67
pubmed: 21545317
Pharm Dev Technol. 2019 Jun;24(5):539-549
pubmed: 30259768
Biomaterials. 2010 Feb;31(6):1334-41
pubmed: 19883937
Top Curr Chem (Cham). 2017 Aug;375(4):71
pubmed: 28712055
Nature. 1994 Jan 27;367(6461):323-4
pubmed: 7509456
J Agric Food Chem. 2019 Jun 12;67(23):6476-6486
pubmed: 31117504
J Pharm Sci. 1969 Oct;58(10):1196-200
pubmed: 5394662