CD4


Journal

Antiviral therapy
ISSN: 2040-2058
Titre abrégé: Antivir Ther
Pays: England
ID NLM: 9815705

Informations de publication

Date de publication:
2020
Historique:
accepted: 12 04 2020
pubmed: 28 4 2020
medline: 5 10 2021
entrez: 28 4 2020
Statut: ppublish

Résumé

Cofactors associated with persistently abnormal CD4 Clinic-based study in a tertiary, university hospital in Madrid. People with HIV starting a first-line ART regimen (January 2006-June 2017) were included in a prospective national multicentre cohort (CoRIS). People with controlled HIV-infection within the first year of ART initiation and complete CD4 The study included 557 subjects. During follow-up (median 5.24 years), 44% of participants achieved a ratio of 1 within a median of 1.49 years. In a multivariate PH model, pre-ART factors negatively associated with ratio normalization were the pre-ART CD4 In summary, our study showed that higher pre-ART CD4

Sections du résumé

BACKGROUND
Cofactors associated with persistently abnormal CD4
METHODS
Clinic-based study in a tertiary, university hospital in Madrid. People with HIV starting a first-line ART regimen (January 2006-June 2017) were included in a prospective national multicentre cohort (CoRIS). People with controlled HIV-infection within the first year of ART initiation and complete CD4
RESULTS
The study included 557 subjects. During follow-up (median 5.24 years), 44% of participants achieved a ratio of 1 within a median of 1.49 years. In a multivariate PH model, pre-ART factors negatively associated with ratio normalization were the pre-ART CD4
CONCLUSIONS
In summary, our study showed that higher pre-ART CD4

Identifiants

pubmed: 32338638
doi: 10.3851/IMP3354
doi:

Substances chimiques

Anti-HIV Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

91-100

Auteurs

Maria J Vivancos-Gallego (MJ)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.

Hajra Okhai (H)

Institute for Global Health, UCL, Royal Free Campus, London, United Kingdom.

Maria J Perez-Elías (MJ)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.

Cristina Gomez-Ayerbe (C)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.

Ana Moreno-Zamora (A)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.

Jose L Casado (JL)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.

Carmen Quereda (C)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.

Javier Martinez Sanz (JM)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.

Matilde Sanchez-Conde (M)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.

Sergio Serrano-Villar (S)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.

Santos Del Campo (S)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.

Fernando Dronda (F)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.

Juan Carlos Galan (JC)

Microbiology Department, IRYCIS, University Hospital Ramón y Cajal, Madrid, Spain.

Caroline A Sabin (CA)

Institute for Global Health, UCL, Royal Free Campus, London, United Kingdom.

Santiago Moreno (S)

Department of Infectious Diseases, University Hospital Ramon y Cajal and Ramón y Cajal Health Research Institute (IRYCIS), Madrid, Spain.
Department of Medicine and Medical Specialties, Alcala University, Madrid, Spain.

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Classifications MeSH