High-frequency cardiopulmonary coupling during sleep correlates with memory in depressed patients: A pilot study.
Cardiopulmonary coupling
High-frequency coupling
Major depressive disorder
Memory
Sleep
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
08
06
2019
revised:
03
01
2020
accepted:
22
03
2020
entrez:
28
4
2020
pubmed:
28
4
2020
medline:
16
2
2021
Statut:
ppublish
Résumé
It has been demonstrated that a reduction in the amount of high-frequency cardiopulmonary coupling (CPC) is indicative of unstable sleep in unmedicated patients with major depressive disorder (MDD). Considering the close relationship between sleep quality and memory consolidation, this study sought to investigate the potential of high-frequency CPC as a novel biomarker for objective evaluation of memory impairment in MDD. A total of 64 depressed patients and 35 healthy controls were included in this cross-sectional study. High-frequency coupling (HFC) was assessed by electrocardiogram-based CPC analysis using a portable sleep-respiration monitor during sleep for one night. The next day, subjects completed the cognition assessment with the Assessment of Neuropsychological Status (RBANS). The 17-Item Hamilton Depression Rating Scale (HAMD There was no significant difference in the proportion of HFC between depressed patients and healthy controls. In patients with low HFC proportion (<35%), severe anxiety could significantly decrease HFC proportion. The HFC proportion positively correlated with immediate and delayed memory in depressed patients. Further analysis showed that patients with low HFC proportion may have worse delayed memory. The lack of prior exposure to the monitoring equipment and procedure could have generated artefacts that would have disappeared after habituation. These results support a positive correlation between the HFC proportion and memory in depressed patients. Further research is required to explore the clinical implications of these findings.
Sections du résumé
BACKGROUND
It has been demonstrated that a reduction in the amount of high-frequency cardiopulmonary coupling (CPC) is indicative of unstable sleep in unmedicated patients with major depressive disorder (MDD). Considering the close relationship between sleep quality and memory consolidation, this study sought to investigate the potential of high-frequency CPC as a novel biomarker for objective evaluation of memory impairment in MDD.
METHODS
A total of 64 depressed patients and 35 healthy controls were included in this cross-sectional study. High-frequency coupling (HFC) was assessed by electrocardiogram-based CPC analysis using a portable sleep-respiration monitor during sleep for one night. The next day, subjects completed the cognition assessment with the Assessment of Neuropsychological Status (RBANS). The 17-Item Hamilton Depression Rating Scale (HAMD
RESULTS
There was no significant difference in the proportion of HFC between depressed patients and healthy controls. In patients with low HFC proportion (<35%), severe anxiety could significantly decrease HFC proportion. The HFC proportion positively correlated with immediate and delayed memory in depressed patients. Further analysis showed that patients with low HFC proportion may have worse delayed memory.
LIMITATIONS
The lack of prior exposure to the monitoring equipment and procedure could have generated artefacts that would have disappeared after habituation.
CONCLUSIONS
These results support a positive correlation between the HFC proportion and memory in depressed patients. Further research is required to explore the clinical implications of these findings.
Identifiants
pubmed: 32339101
pii: S0165-0327(19)31510-1
doi: 10.1016/j.jad.2020.03.058
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
118-123Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflicts of interest.