The effect of rapamycin on bovine oocyte maturation success and metaphase telomere length maintenance.
blastocysts
oocytes
rapamycin
reproductive aging
telomere
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
27 04 2020
27 04 2020
Historique:
received:
25
02
2020
accepted:
30
03
2020
pubmed:
28
4
2020
medline:
24
2
2021
entrez:
28
4
2020
Statut:
ppublish
Résumé
Maternal aging-associated reduction of oocyte viability is a common feature in mammals, but more research is needed to counteract this process. In women, the first aging phenotype appears with a decline in reproductive function, and the follicle number gradually decreases from menarche to menopause. Cows can be used as a model of early human embryonic development and reproductive aging because both species share a very high degree of similarity during follicle selection, cleavage, and blastocyst formation. Recently, it has been proposed that the main driver of aging is the mammalian target of rapamycin (mTOR) signaling rather than reactive oxygen species. Based on these observations, the study aimed to investigate for the first time the possible role of rapamycin on oocyte maturation, embryonic development, and telomere length in the bovine species, as a target for future strategies for female infertility caused by advanced maternal age. The 1nm rapamycin
Identifiants
pubmed: 32339158
doi: 10.18632/aging.103126
pii: 103126
pmc: PMC7202508
doi:
Substances chimiques
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7576-7584Références
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