Transcriptomic analysis of sea star development through metamorphosis to the highly derived pentameral body plan with a focus on neural transcription factors.
Parvulastra exigua
developmental transcriptome
metamorphosis
radial body plan
starfish
Journal
DNA research : an international journal for rapid publication of reports on genes and genomes
ISSN: 1756-1663
Titre abrégé: DNA Res
Pays: England
ID NLM: 9423827
Informations de publication
Date de publication:
01 Feb 2020
01 Feb 2020
Historique:
received:
11
11
2019
accepted:
20
04
2020
pubmed:
28
4
2020
medline:
12
3
2021
entrez:
28
4
2020
Statut:
ppublish
Résumé
The Echinodermata is characterized by a secondarily evolved pentameral body plan. While the evolutionary origin of this body plan has been the subject of debate, the molecular mechanisms underlying its development are poorly understood. We assembled a de novo developmental transcriptome from the embryo through metamorphosis in the sea star Parvulastra exigua. We use the asteroid model as it represents the basal-type echinoderm body architecture. Global variation in gene expression distinguished the gastrula profile and showed that metamorphic and juvenile stages were more similar to each other than to the pre-metamorphic stages, pointing to the marked changes that occur during metamorphosis. Differential expression and gene ontology (GO) analyses revealed dynamic changes in gene expression throughout development and the transition to pentamery. Many GO terms enriched during late metamorphosis were related to neurogenesis and signalling. Neural transcription factor genes exhibited clusters with distinct expression patterns. A suite of these genes was up-regulated during metamorphosis (e.g. Pax6, Eya, Hey, NeuroD, FoxD, Mbx, and Otp). In situ hybridization showed expression of neural genes in the CNS and sensory structures. Our results provide a foundation to understand the metamorphic transition in echinoderms and the genes involved in development and evolution of pentamery.
Identifiants
pubmed: 32339242
pii: 5825731
doi: 10.1093/dnares/dsaa007
pmc: PMC7315356
pii:
doi:
Substances chimiques
Transcription Factors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NICHD NIH HHS
ID : T32 HD040372
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.
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