APPL1 as an important regulator of insulin and adiponectin-signaling pathways in the PCOS: A narrative review.
Adaptor Proteins, Signal Transducing
/ physiology
Adiponectin
/ metabolism
Animals
Endometrium
/ metabolism
Female
Humans
Insulin
/ physiology
Mice
Ovarian Follicle
/ growth & development
Ovary
/ metabolism
Polycystic Ovary Syndrome
/ metabolism
Receptor, Insulin
/ metabolism
Signal Transduction
Uterus
/ metabolism
PTB domain and leucine zipper motif 1 (APPL1)
adaptor protein containing a PH domain
adiponectin
insulin resistance
ovulation
polycystic ovary syndrome (PCOS)
steroidogenesis
Journal
Cell biology international
ISSN: 1095-8355
Titre abrégé: Cell Biol Int
Pays: England
ID NLM: 9307129
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
16
12
2019
revised:
09
04
2020
accepted:
25
04
2020
pubmed:
28
4
2020
medline:
30
3
2021
entrez:
28
4
2020
Statut:
ppublish
Résumé
Adaptor protein containing a PH domain, PTB domain and leucine zipper motif 1 (APPL1) plays a central role as the main contributing factor in the adiponectin and insulin signaling. This review aims to discuss previous and recent findings concerning the role of APPL1 in the polycystic ovary syndrome (PCOS) patients with conclusions regarding more efficient therapeutic approaches. A literature review was performed in PubMed, Web of Science, ScienceDirect, Scopus, and Google Scholar from August 1999 to May 2020. This study reveals that APPL1 has a key role in adiponectin, insulin, and follicle-stimulating hormone signaling pathways occurring within the ovaries. Recent studies in mouse model systems have indicated that APPL1 can prevent diabetes, endothelial disorders, and insulin resistance. In contrast, APPL1 deficiency can lead to the metabolic and vascular disorders. APPL1 due to its potential roles in different signaling pathways might be suggested as a novel diagnostic and therapeutic option for prediction of ovarian dysfunctions and treatment of reproductive disorders, especially PCOS.
Substances chimiques
APPL1 protein, human
0
Adaptor Proteins, Signal Transducing
0
Adiponectin
0
Insulin
0
Receptor, Insulin
EC 2.7.10.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1577-1587Informations de copyright
© 2020 International Federation for Cell Biology.
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