Dynamics of effector and naïve Regulatory T cells throughout pregnancy.
CD45RA
Foxp3
Regulatory T cell
pregnancy
Journal
Journal of reproductive immunology
ISSN: 1872-7603
Titre abrégé: J Reprod Immunol
Pays: Ireland
ID NLM: 8001906
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
05
11
2019
revised:
10
04
2020
accepted:
13
04
2020
pubmed:
28
4
2020
medline:
28
8
2021
entrez:
28
4
2020
Statut:
ppublish
Résumé
Regulatory T (Treg) cells are a specialized subset of T cells possessing immunosuppressive functions indispensable for the maintenance of self-tolerance and pregnancy. However, how functional Treg cells dynamically change and are engaged in feto-maternal tolerance during human pregnancy is still unclear. Recent studies have shown that functionally distinct and immunosuppressive subsets of Treg cells, i.e., effector Treg (eTreg) and naïve Treg (nTreg) cells, can be delineated by combinations of molecular markers and that their proportions differ in normal and disease states. In this study, we examined how the proportion of eTreg and nTreg cells in peripheral blood changes in the 1
Identifiants
pubmed: 32339846
pii: S0165-0378(20)30056-5
doi: 10.1016/j.jri.2020.103135
pii:
doi:
Substances chimiques
FOXP3 protein, human
0
Forkhead Transcription Factors
0
Proto-Oncogene Proteins c-bcl-2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103135Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.