A preliminary study to investigate resting state fMRI as a potential group differentiator for schizophrenia.
Brain areas
Functional connectivity
Group differentiator
Resting state fMRI
Schizophrenia
Journal
Asian journal of psychiatry
ISSN: 1876-2026
Titre abrégé: Asian J Psychiatr
Pays: Netherlands
ID NLM: 101517820
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
23
06
2019
revised:
13
03
2020
accepted:
07
04
2020
pubmed:
28
4
2020
medline:
22
6
2021
entrez:
28
4
2020
Statut:
ppublish
Résumé
Schizophrenia (SZ) is found to be associated with dysconnectivity between the various regions of the brain. These aberrant connections in brain networks responsible for various mental processes in schizophrenia. We examined differences in functional connectivity among persons with SZ (n = 30) and an equal number of their unaffected relatives using resting state functional Magnetic Resonance Imaging (rsfMRI). Subjects were interviewed using the Diagnostic Interview for Genetic Studies (DIGS) and Family Interview for Genetic Studies (FIGS). Cognition was assessed using the Computerized Neuropsychological Battery (CNB) and Trail Making Tests A and B. The resting state functional data were acquired using 3.0 T Magnetic Resonance Imaging system and analysed using Statistical Package for the Social Sciences (SPSS) version 21 and FSL version 5.01 (FMRIB's) Software. The persons with SZ performed significantly worse on tasks of cognition and executive functioning. On rsfMRI, a significantly reduced connectivity was noted in the case group in right and left precentral gyri, right post central gyrus, right and left middle temporal gyrus, left paracingulate gyrus, anterior and posterior cingulate, right planum temporale, right pallidum, left cerebellum-6,7b and 8 lobules. Increased connectivity was noted between areas of right temporal pole and left hippocampus, posterior cingulate and the precuneus, right planum polare and right amygdala, right Heschl's gyrus and left posterior supramarginal gyrus, right amygdala with right insular cortex and left cerebellum 6 with bilateral postcentral gyrus in the same group. These differences in connectivity could be utilised as potential group differentiator for schizophrenia.
Identifiants
pubmed: 32339919
pii: S1876-2018(20)30206-9
doi: 10.1016/j.ajp.2020.102095
pmc: PMC10154078
mid: NIHMS1870918
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102095Subventions
Organisme : FIC NIH HHS
ID : D43 TW009114
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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