Microbiomes as modulators of Drosophila melanogaster homeostasis and disease.
Journal
Current opinion in insect science
ISSN: 2214-5753
Titre abrégé: Curr Opin Insect Sci
Pays: Netherlands
ID NLM: 101635599
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
21
02
2020
revised:
09
03
2020
accepted:
15
03
2020
pubmed:
28
4
2020
medline:
5
1
2021
entrez:
28
4
2020
Statut:
ppublish
Résumé
Drosophila melanogaster harbors a simple gut microbial community, or microbiome, that regulates several facets of its physiology. As a result, the host employs multiple mechanisms of maintaining control over its microbiome in an effort to promote overall organismal homeostasis. Perturbations to the balance between microbiome and host can result in states of instability or disease, making maintenance of microbial homeostasis a fundamental physiologic aspect of D. melanogaster biology. While the interactions between microbes and their hosts can be direct, particularly in the context of immunity and gut renewal, effects resulting from indirect interactions, such as those between microbiota members, can be equally as important. This review highlights the major ways, in which D. melanogaster regulates microbial homeostasis, the consequences of disruptions to homeostasis, and the different mechanisms, by which the microbiome interacts with its host.
Identifiants
pubmed: 32339931
pii: S2214-5745(20)30039-0
doi: 10.1016/j.cois.2020.03.003
pmc: PMC7302976
mid: NIHMS1578468
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
84-90Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM128871
Pays : United States
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
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