Intestinal Permeability, Inflammation and the Role of Nutrients.
Digestion
Gastrointestinal Absorption
/ physiology
Gastrointestinal Diseases
/ etiology
Gastrointestinal Microbiome
/ physiology
Gastrointestinal Tract
/ metabolism
Homeostasis
Humans
Immunity, Mucosal
/ immunology
Intestinal Mucosa
/ immunology
Nutrients
/ metabolism
Nutritional Physiological Phenomena
/ physiology
amino acids
epithelial integrity
mucosal barrier
nutrients
short-chain fatty acids
vitamins
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
23 Apr 2020
23 Apr 2020
Historique:
received:
27
11
2019
revised:
10
04
2020
accepted:
17
04
2020
entrez:
29
4
2020
pubmed:
29
4
2020
medline:
26
2
2021
Statut:
epublish
Résumé
The interaction between host and external environment mainly occurs in the gastrointestinal tract, where the mucosal barrier has a critical role in many physiologic functions ranging from digestion, absorption, and metabolism. This barrier allows the passage and absorption of nutrients, but at the same time, it must regulate the contact between luminal antigens and the immune system, confining undesirable products to the lumen. Diet is an important regulator of the mucosal barrier, and the cross-talk among dietary factors, the immune system, and microbiota is crucial for the modulation of intestinal permeability and for the maintenance of gastrointestinal tract (GI) homeostasis. In the present review, we will discuss the role of a number of dietary nutrients that have been proposed as regulators of inflammation and epithelial barrier function. We will also consider the metabolic function of the microbiota, which is capable of elaborating the diverse nutrients and synthesizing products of great interest. Better knowledge of the influence of dietary nutrients on inflammation and barrier function can be important for the future development of new therapeutic approaches for patients with mucosal barrier dysfunction, a critical factor in the pathogenesis of many GI and non-GI diseases.
Identifiants
pubmed: 32340206
pii: nu12041185
doi: 10.3390/nu12041185
pmc: PMC7231157
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)
ID : EHD16PI02
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