A Systems Biological Approach to Understanding the Mechanisms Underlying the Therapeutic Potential of Red Ginseng Supplements against Metabolic Diseases.
Panax ginseng
metabolic disease
network analysis
red ginseng
systems biology
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
23 Apr 2020
23 Apr 2020
Historique:
received:
27
03
2020
revised:
17
04
2020
accepted:
21
04
2020
entrez:
29
4
2020
pubmed:
29
4
2020
medline:
30
1
2021
Statut:
epublish
Résumé
Red ginseng has been widely used in health-promoting supplements in Asia and is becoming increasingly popular in Western countries. However, its therapeutic mechanisms against most diseases have not been clearly elucidated. The aim of the present study was to provide the biological mechanisms of red ginseng against various metabolic diseases. We used a systems biological approach to comprehensively identify the component-target and target-pathway networks in order to explore the mechanisms underlying the therapeutic potential of red ginseng against metabolic diseases. Of the 23 components of red ginseng with target, 5 components were linked with 37 target molecules. Systematic analysis of the constructed networks revealed that these 37 targets were mainly involved in 9 signaling pathways relating to immune cell differentiation and vascular health. These results successfully explained the mechanisms underlying the efficiency of red ginseng for metabolic diseases, such as menopausal symptoms in women, blood circulation, diabetes mellitus, and hyperlipidemia.
Identifiants
pubmed: 32340247
pii: molecules25081967
doi: 10.3390/molecules25081967
pmc: PMC7221703
pii:
doi:
Substances chimiques
Biomarkers
0
Plant Extracts
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Korea Ginseng Corporation
ID : not applicable
Organisme : National Research Foundation (NRF)
ID : 2012M3A9C4048761
Références
J Biol Chem. 2001 Mar 9;276(10):7614-20
pubmed: 11108718
J Am Coll Nutr. 2006 Apr;25(2):100-7
pubmed: 16582025
Int Immunopharmacol. 2017 Jun;47:118-125
pubmed: 28384530
J Med Food. 2014 Jan;17(1):128-34
pubmed: 24456363
Per Med. 2010 May;7(3):275-289
pubmed: 20577569
J Ginseng Res. 2018 Oct;42(4):549-561
pubmed: 30337816
Theranostics. 2017 Jan 15;7(3):733-750
pubmed: 28255363
Asia Pac J Clin Nutr. 2013;22(3):365-71
pubmed: 23945406
BMC Complement Altern Med. 2014 Jul 11;14:237
pubmed: 25015735
Am J Chin Med. 2010;38(3):485-93
pubmed: 20503467
Cell Physiol Biochem. 2018;51(4):1739-1750
pubmed: 30504696
J Ethnopharmacol. 2014 Dec 2;158 Pt A:25-32
pubmed: 25284751
Am J Chin Med. 2011;39(3):441-50
pubmed: 21598413
Evid Based Complement Alternat Med. 2015;2015:913158
pubmed: 26798402
J Ethnopharmacol. 2011 Sep 1;137(1):245-50
pubmed: 21619921
Bioinformatics. 2019 Feb 1;35(3):497-505
pubmed: 30020411
Am J Hypertens. 2010 May;23(5):469-72
pubmed: 20134405
Breast Cancer Res Treat. 2011 Oct;129(3):887-99
pubmed: 21523452
Chin J Integr Med. 2011 Dec;17(12):937-44
pubmed: 22139546
Genome Med. 2016 Apr 20;8(1):42
pubmed: 27098727
BMC Public Health. 2010 Jan 27;10:38
pubmed: 20529387
J Alzheimers Dis. 2009;18(2):339-44
pubmed: 19584437
Biomed Pharmacother. 2018 Oct;106:1091-1097
pubmed: 30119175
Front Pharmacol. 2018 Nov 02;9:1227
pubmed: 30450046
J Med Food. 2013 May;16(5):383-95
pubmed: 23675990
Food Chem. 2011 Apr 15;125(4):1299-1305
pubmed: 21344064
J Agric Food Chem. 2009 Mar 25;57(6):2363-7
pubmed: 19256509
Cochrane Database Syst Rev. 2010 Dec 08;(12):CD007769
pubmed: 21154383
Gastroenterology. 2017 Aug;153(2):521-535.e20
pubmed: 28438610
Lancet Oncol. 2001 Jan;2(1):49-55
pubmed: 11905620
Sci Rep. 2017 Aug 8;7(1):7519
pubmed: 28790372
J Korean Med Sci. 2016 Dec;31(12):1879-1886
pubmed: 27822924
J Am Coll Nutr. 2004 Jun;23(3):248-58
pubmed: 15190050
Ann Pharmacother. 2006 Jan;40(1):83-95
pubmed: 16332943
J Ginseng Res. 2014 Apr;38(2):97-105
pubmed: 24748833
Menopause. 2012 Apr;19(4):461-6
pubmed: 22027944
Sci Rep. 2017 Nov 27;7(1):16364
pubmed: 29180652
J Tradit Chin Med. 2013 Feb;33(1):39-45
pubmed: 23596810
Int J Sport Nutr Exerc Metab. 2009 Jun;19(3):298-322
pubmed: 19574616
Nat Rev Drug Discov. 2007 Mar;6(3):202-10
pubmed: 17318209
J Ethnopharmacol. 2015 Jan 15;159:55-61
pubmed: 25446600